دورية أكاديمية
أعرض في EDS

Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil.

التفاصيل البيبلوغرافية
العنوان: Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil.
المؤلفون: Janovsky CCPS; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil.; Division of Endocrinology, Federal University of São Paulo/Escola Paulista de Medicina, São Paulo 04039-032, Brazil., Meneghini V; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil., Tebar W; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil., Martins JRM; Division of Endocrinology, Federal University of São Paulo/Escola Paulista de Medicina, São Paulo 04039-032, Brazil., Sgarbi JA; Division of Endocrinology, Faculty of Medicine of Marília (FAMEMA), Marília 17519-030, Brazil., Teixeira PFDS; Medicine School, Federal University of Rio de Janeiro, Rio de Janeiro 21044-020, Brazil., Jones SR; Johns Hopkins, Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD 21287, USA., Blaha MJ; Johns Hopkins, Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD 21287, USA., Toth PP; CGH Medical Center, Department of Preventive Cardiology, Sterling, IL 61081, USA., Lotufo PA; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil., Bittencourt MS; Department of Medicine and Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Santos RD; Heart Institute (InCor), University of São Paulo, São Paulo 05403-900, Brazil.; Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil., Santos IS; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil., Chaker L; Department of Internal Medicine and Rotterdam Thyroid Center, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Bensenor IM; Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo 05508-000, Brazil.
المصدر: Metabolites [Metabolites] 2024 Aug 06; Vol. 14 (8). Date of Electronic Publication: 2024 Aug 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain amino acids (BCAAs-leucine, isoleucine, and valine) and of alanine in the general population. We utilized data from the São Paulo research center of ELSA-Brasil, a longitudinal population-based cohort study. Thyroid parameters included thyroid stimulating hormone (TSH), free T4 and free T3 levels, and the FT4:FT3 ratio. BCAAs and alanine were analyzed on a fully automated NMR platform. The current analysis included euthyroid participants and participants with subclinical hyperthyroidism and hypothyroidism. We used Pearson's coefficient to quantify the correlation between thyroid-related parameters and amino acids. Linear regression models were performed to analyze whether thyroid parameters were associated with BCAAs and alanine levels. We included 4098 participants (51.3 ± 9.0 years old, 51.5% women) in this study. In the most adjusted model, higher levels of TSH were associated with higher levels of alanine, FT4 levels were inversely associated with isoleucine levels, FT3 levels were statistically significant and positively associated with valine and leucine, and the T3:T4 ratio was positively associated with all amino acids. We observed that subclinical hypothyroidism was positively associated with isoleucine and alanine levels in all models, even after full adjustment. Our findings highlight the association of subclinical hypothyroidism and thyroid-related parameters (including TSH, free T4, free T3, and FT4:FT3 ratio) with BCAAs and alanine. Further studies are needed to explore the mechanisms underlying this association. These insights contribute to our understanding of the influence of thyroid-related parameters on BCAA and alanine metabolism.
References: Poult Sci. 1998 Feb;77(2):295-8. (PMID: 9495496)
Lancet Healthy Longev. 2023 Feb;4(2):e72-e82. (PMID: 36738747)
Clinics (Sao Paulo). 2016 Apr;71(4):221-5. (PMID: 27166773)
Diabetes Res Clin Pract. 2021 Apr;174:108747. (PMID: 33713721)
Eur J Clin Invest. 1988 Feb;18(1):62-8. (PMID: 3130261)
Annu Rev Physiol. 2019 Feb 10;81:139-164. (PMID: 30485760)
Nat Rev Endocrinol. 2014 Dec;10(12):723-36. (PMID: 25287287)
Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1067-73. (PMID: 15657093)
BMC Cardiovasc Disord. 2018 Sep 10;18(1):181. (PMID: 30200880)
Cell Biochem Funct. 2021 Aug;39(6):754-762. (PMID: 33913177)
Autophagy. 2019 Jan;15(1):131-150. (PMID: 30209975)
Clin Endocrinol (Oxf). 2017 Jul;87(1):87-96. (PMID: 28374508)
Scand J Clin Lab Invest. 2020 Nov;80(7):562-566. (PMID: 32838571)
Int J Epidemiol. 2015 Feb;44(1):68-75. (PMID: 24585730)
Front Endocrinol (Lausanne). 2022 Oct 27;13:1044691. (PMID: 36387853)
J Clin Endocrinol Metab. 2000 Feb;85(2):697-706. (PMID: 10690879)
Front Physiol. 2021 Oct 18;12:606931. (PMID: 34733168)
J Biol Chem. 1974 Dec 10;249(23):7623-9. (PMID: 4436328)
J Endocr Soc. 2019 May 16;3(7):1345-1356. (PMID: 31286098)
J Inherit Metab Dis. 1996;19(4):470-7. (PMID: 8884571)
Am J Epidemiol. 2012 Feb 15;175(4):315-24. (PMID: 22234482)
Metabolism. 2013 Jul;62(7):961-9. (PMID: 23375209)
Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. (PMID: 12900694)
Mitochondrion. 2014 Jul;17:76-100. (PMID: 24929216)
Front Endocrinol (Lausanne). 2018 May 23;9:254. (PMID: 29875734)
Front Endocrinol (Lausanne). 2022 Nov 28;13:1067801. (PMID: 36518251)
Biomolecules. 2023 Aug 29;13(9):. (PMID: 37759723)
J Clin Endocrinol Metab. 2008 Oct;93(10):3999-4005. (PMID: 18628521)
Neurochem Res. 2017 Jun;42(6):1697-1709. (PMID: 28417264)
Biosci Rep. 2016 Nov 29;36(6):. (PMID: 27707936)
Nutrients. 2017 Jun 22;9(7):. (PMID: 28640216)
Metab Syndr Relat Disord. 2017 May;15(4):183-186. (PMID: 28437198)
Cell Metab. 2009 Apr;9(4):311-26. (PMID: 19356713)
Horm Mol Biol Clin Investig. 2017 Jan 18;31(1):. (PMID: 28099124)
Diabetes. 2004 Mar;53(3):577-84. (PMID: 14988240)
Diabetes. 1982 Jan;31(1):86-9. (PMID: 7152124)
Front Physiol. 2021 Jul 20;12:702826. (PMID: 34354601)
Poult Sci. 1997 Oct;76(10):1398-404. (PMID: 9316116)
Klin Wochenschr. 1984 Jan 2;62(1):11-8. (PMID: 6321848)
Thyroid. 2021 Mar;31(3):519-527. (PMID: 33019884)
Int J Behav Nutr Phys Act. 2011 Oct 21;8:115. (PMID: 22018588)
Rev Saude Publica. 2013 Jun;47 Suppl 2:37-47. (PMID: 24346719)
Nutr Metab (Lond). 2018 May 3;15:33. (PMID: 29755574)
Nutrients. 2022 Mar 10;14(6):. (PMID: 35334826)
J Thyroid Res. 2021 Sep 28;2021:1865483. (PMID: 35140907)
Front Endocrinol (Lausanne). 2015 Nov 20;6:177. (PMID: 26635726)
Sci Rep. 2016 Apr 15;6:24540. (PMID: 27080554)
Arch Biochem Biophys. 2000 Mar 1;375(1):55-61. (PMID: 10683248)
J Pathol. 2012 Jun;227(2):209-22. (PMID: 22294347)
Appl Physiol Nutr Metab. 2012 Jun;37(3):395-406. (PMID: 22509811)
Sci Rep. 2022 Mar 7;12(1):3693. (PMID: 35256693)
Clin Biochem. 2014 Nov;47(16-17):203-10. (PMID: 25079243)
Clin Lab Med. 2006 Dec;26(4):847-70. (PMID: 17110242)
Nutrients. 2022 Dec 23;15(1):. (PMID: 36615726)
Science. 1970 Feb 13;167(3920):1003-4. (PMID: 5411169)
Rev Saude Publica. 2013 Jun;47 Suppl 2:72-8. (PMID: 24346723)
Curr Opin Clin Nutr Metab Care. 2014 Jan;17(1):86-9. (PMID: 24310057)
Int J Vitam Nutr Res. 2011 Mar;81(2-3):101-7. (PMID: 22139560)
Cells. 2019 Mar 18;8(3):. (PMID: 30889829)
Int J Epidemiol. 2021 Aug 30;50(4):1058-1063. (PMID: 34050649)
معلومات مُعتمدة: grants of baseline: 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ; and grants of 4-year follow-up 01 10 0643-03 RS, 01 10 0742-00 BA, 01 12 0284-00 ES, 01 10 0746-00 MG, 01 10 0773-00 SP, and 01 National Council for Scientific and Technological Development; 2015/17213- 2 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: BCAAs; NMR spectroscopy; amino acids; hypothyroidism; thyroid
تواريخ الأحداث: Date Created: 20240828 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC11356049
DOI: 10.3390/metabo14080437
PMID: 39195533
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo14080437