دورية أكاديمية
أعرض في EDS

Impact of Frailty on Post-Treatment Dysphagia in Patients with Head and Neck Cancer.

التفاصيل البيبلوغرافية
العنوان: Impact of Frailty on Post-Treatment Dysphagia in Patients with Head and Neck Cancer.
المؤلفون: Hurtado-Oliva J; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands. j.a.hurtado.oliva@umcg.nl.; Departamento de Fonoaudiología, Facultad de Medicina, Universidad de Chile, Santiago, Chile. j.a.hurtado.oliva@umcg.nl., van der Laan HP; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., de Vries J; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands., Steenbakkers RJHM; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Halmos GB; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands., Wegner I; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1 , PO box 30.001, Groningen, 9700RB, the Netherlands.
المصدر: Dysphagia [Dysphagia] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 8610856 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0460 (Electronic) Linking ISSN: 0179051X NLM ISO Abbreviation: Dysphagia Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer-Verlag, [c1986-
مستخلص: In the rising and frail head and neck cancer (HNC) population, geriatric assessments are crucial. Frail HNC patients often experience dysphagia. The coexistence of dysphagia and frailty presents complex health challenges, however, there is limited evidence on the prognostic value of frailty on post-treatment dysphagia. This study explores the relationship between pre-treatment frailty status and post-treatment dysphagia in HNC patients. A retrospective data analysis from the OncoLifeS data-biobank at the University Medical Center Groningen of 242 patients diagnosed with HNC between 2014 and 2016. The study involved several physical, functional and psychological pre-treatment geriatric assessments, and frailty screening using the Groningen Frailty Indicator (GFI) and the Geriatric-8 screening tool (G8). Outcome measures were swallowing-related quality of life (HNSW-QoL) and toxicity-related dysphagia evaluations (CTCAE-D) at 3, 6, 12 and 24 months. Linear mixed-effects models assessed factors associated with HNSW-QoL and CTCAE-D. Frail patients consistently reported worse HNSW-QoL and CTCAE-D than non-frail patients over time, with symptoms increasing at 3 months, but gradually decreasing by 24 months. Frailty status (G8 or GFI) was a significant predictor for lower HNSW-QoL (β = 11.770 and 10.936, both p < 0.001), and lower CTCAE-D (β = 0.245, p = 0.058; β = 0.331, p = 0.019), respectively. In this study, frailty was found to be associated with a worse of swallowing-related quality of life, and with increased toxicity-related dysphagia. These findings provide insights for the identification of HNC patients at higher risk of post-treatment swallowing-related issues, and offer opportunities for optimizing their post-treatment swallowing outcomes.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 72210512 Agencia Nacional de Investigación y Desarrollo
فهرسة مساهمة: Keywords: Dysphagia; Frailty; Geriatric assessment; Head and neck cancer; Toxicity
تواريخ الأحداث: Date Created: 20240828 Latest Revision: 20240828
رمز التحديث: 20240828
DOI: 10.1007/s00455-024-10754-7
PMID: 39196352
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0460
DOI:10.1007/s00455-024-10754-7