Health and economic impacts of Lassa vaccination campaigns in West Africa.

التفاصيل البيبلوغرافية
العنوان:	Health and economic impacts of Lassa vaccination campaigns in West Africa.
المؤلفون:	Smith DRM; Nuffield Department of Population Health, Health Economics Research Centre, University of Oxford, Oxford, UK. david.smith@ndph.ox.ac.uk., Turner J; Department of Mathematical Sciences, University of Liverpool, Liverpool, UK.; Department of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Fahr P; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Attfield LA; Department of Genetics, Evolution and Environment, Centre for Biodiversity and Environment Research, University College London, London, UK.; Department of Infectious Disease Epidemiology, Imperial College London, London, UK., Bessell PR; Independent consultant, Edinburgh, UK., Donnelly CA; Department of Infectious Disease Epidemiology, Imperial College London, London, UK.; Department of Statistics, University of Oxford, Oxford, UK.; Pandemic Sciences Institute, University of Oxford, Oxford, UK., Gibb R; Department of Genetics, Evolution and Environment, Centre for Biodiversity and Environment Research, University College London, London, UK., Jones KE; Department of Genetics, Evolution and Environment, Centre for Biodiversity and Environment Research, University College London, London, UK., Redding DW; Science Department, The Natural History Museum, London, UK., Asogun D; Irrua Specialist Teaching Hospital, Irrua, Nigeria., Ayodeji OO; Federal Medical Centre, Owo, Nigeria., Azuogu BN; Alex Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Nigeria., Fischer WA 2nd; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Jan K; Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria., Olayinka AT; Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria., Wohl DA; Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Torkelson AA; Linksbridge SPC, Seattle, WA, USA., Dinkel KA; Linksbridge SPC, Seattle, WA, USA., Nixon EJ; Department of Mathematical Sciences, University of Liverpool, Liverpool, UK., Pouwels KB; Nuffield Department of Population Health, Health Economics Research Centre, University of Oxford, Oxford, UK., Hollingsworth TD; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, NDM Centre for Global Health Research, University of Oxford, Oxford, UK.
المصدر:	Nature medicine [Nat Med] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: New York Ny : Nature Publishing Company Original Publication: New York, NY : Nature Pub. Co., [1995-
مستخلص:	Lassa fever is a zoonotic disease identified by the World Health Organization (WHO) as having pandemic potential. This study estimates the health-economic burden of Lassa fever throughout West Africa and projects impacts of a series of vaccination campaigns. We also model the emergence of 'Lassa-X'-a hypothetical pandemic Lassa virus variant-and project impacts of achieving 100 Days Mission vaccination targets. Our model predicted 2.7 million (95% uncertainty interval: 2.1-3.4 million) Lassa virus infections annually, resulting over 10 years in 2.0 million (793,800-3.9 million) disability-adjusted life years (DALYs). The most effective vaccination strategy was a population-wide preventive campaign primarily targeting WHO-classified 'endemic' districts. Under conservative vaccine efficacy assumptions, this campaign averted $20.1 million ($8.2-$39.0 million) in lost DALY value and $128.2 million ($67.2-$231.9 million) in societal costs (2021 international dollars ($)). Reactive vaccination in response to local outbreaks averted just one-tenth the health-economic burden of preventive campaigns. In the event of Lassa-X emerging, spreading throughout West Africa and causing approximately 1.2 million DALYs within 2 years, 100 Days Mission vaccination averted 22% of DALYs given a vaccine 70% effective against disease and 74% of DALYs given a vaccine 70% effective against both infection and disease. These findings suggest how vaccination could alleviate Lassa fever's burden and assist in pandemic preparedness. (© 2024. The Author(s).)
التعليقات:	Update of: medRxiv. 2024 Jun 30:2024.02.26.24303394. doi: 10.1101/2024.02.26.24303394. (PMID: 38978680)
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تواريخ الأحداث:	Date Created: 20240828 Latest Revision: 20240903
رمز التحديث:	20240903
DOI:	10.1038/s41591-024-03232-y
PMID:	39198710
قاعدة البيانات:	MEDLINE

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تدمد:	1546-170X
DOI:	10.1038/s41591-024-03232-y