دورية أكاديمية
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Differential Chemical Components Analysis of Periplocae Cortex , Lycii Cortex , and Acanthopanacis Cortex Based on Mass Spectrometry Data and Chemometrics.

التفاصيل البيبلوغرافية
العنوان: Differential Chemical Components Analysis of Periplocae Cortex , Lycii Cortex , and Acanthopanacis Cortex Based on Mass Spectrometry Data and Chemometrics.
المؤلفون: Wang X; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., Zhang J; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., He F; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; Institute for College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China., Jing W; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., Li M; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., Guo X; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., Cheng X; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China., Wei F; Institute for Control of Traditional Chinese Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 102629, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Aug 11; Vol. 29 (16). Date of Electronic Publication: 2024 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/analysis , Principal Component Analysis* , Mass Spectrometry*/methods, Chromatography, High Pressure Liquid/methods ; Chemometrics ; Discriminant Analysis ; Least-Squares Analysis ; Plant Bark/chemistry ; Medicine, Chinese Traditional
مستخلص: Background: Periplocae Cortex (PC), Acanthopanacis Cortex (AC), and Lycii Cortex (LC), as traditional Chinese medicines, are all dried root bark, presented in a roll, light and brittle, easy to break, have a fragrant scent, etc. Due to their similar appearances, it is tough to distinguish them, and they are often confused and adulterated in markets and clinical applications. To realize the identification and quality control of three herbs, in this paper, Ultra Performance Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry Expression (UHPLC-QTOF-MS E ) combined with chemometric analysis was used to explore the different chemical compositions. Methods: LC, AC, and PC were analyzed by UHPLC-QTOF-MS E , and the quantized MS data combined with Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) were used to explore the different chemical compositions with Variable Importance Projection (VIP) > 1.0. Further, the different chemical compositions were identified according to the chemical standard substances, related literature, and databases. Results: AC, PC, and LC can be obviously distinguished in PCA and PLS-DA analysis with the VIP of 2661 ions > 1.0. We preliminarily identified 17 differential chemical constituents in AC, PC, and LC with significant differences ( p < 0.01) and VIP > 1.0; for example, Lycium B and Periploside H2 are LC and PC's proprietary ingredients, respectively, and 2-Hydroxy-4-methoxybenzaldehyde, Periplocoside C, and 3,5-Di-O-caffeoylquinic acid are the shared components of the three herbs. Conclusions: UHPLC-QTOF-MS E combined with chemometric analysis is conducive to exploring the differential chemical compositions of three herbs. Moreover, the proprietary ingredients, Lycium B (LC) and Periploside H2 (PC), are beneficial in strengthening the quality control of AC, PC, and LC. In addition, limits on the content of shared components can be set to enhance the quality control of LC, PC, and AC.
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معلومات مُعتمدة: 2023YFC3504105 the National Key R&D Program of China
فهرسة مساهمة: Keywords: Acanthopanacis Cortex; Lycii Cortex; Periplocae Cortex; chemometric analysis; partial least squares discriminant analysis; principal component analysis
المشرفين على المادة: 0 (Drugs, Chinese Herbal)
تواريخ الأحداث: Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240901
رمز التحديث: 20240902
مُعرف محوري في PubMed: PMC11357377
DOI: 10.3390/molecules29163807
PMID: 39202886
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29163807