دورية أكاديمية
أعرض في EDS

Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of Helicobacter pylori .

التفاصيل البيبلوغرافية
العنوان: Optical Biosensor Based on Porous Silicon and Tamm Plasmon Polariton for Detection of CagA Antigen of Helicobacter pylori .
المؤلفون: Rong G; CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, China., Kavokin A; The International Center for Polaritonics, School of Sciences, Westlake University, Hangzhou 310030, China., Sawan M; CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, China.
المصدر: Sensors (Basel, Switzerland) [Sensors (Basel)] 2024 Aug 09; Vol. 24 (16). Date of Electronic Publication: 2024 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2000-
مواضيع طبية MeSH: Biosensing Techniques*/methods , Silicon*/chemistry , Helicobacter pylori*/immunology , Helicobacter pylori*/isolation & purification , Antigens, Bacterial*/immunology , Antigens, Bacterial*/analysis , Bacterial Proteins*/immunology, Porosity ; Humans ; Helicobacter Infections/diagnosis ; Helicobacter Infections/microbiology
مستخلص: Helicobacter pylori ( H. pylori ) is a common pathogen with a high prevalence of infection in human populations. The diagnosis of H. pylori infection is critical for its treatment, eradication, and prognosis. Biosensors have been demonstrated to be powerful for the rapid onsite detection of pathogens, particularly for point-of-care test (POCT) scenarios. In this work, we propose a novel optical biosensor, based on nanomaterial porous silicon (PSi) and photonic surface state Tamm Plasmon Polariton (TPP), for the detection of cytotoxin-associated antigen A (CagA) of H. pylori bacterium. We fabricated the PSi TPP biosensor, analyzed its optical characteristics, and demonstrated through experiments, with the sensing of the CagA antigen, that the TPP biosensor has a sensitivity of 100 pm/(ng/mL), a limit of detection of 0.05 ng/mL, and specificity in terms of positive-to-negative ratio that is greater than six. From these performance factors, it can be concluded that the TPP biosensor can serve as an effective tool for the diagnosis of H. pylori infection, either in analytical labs or in POCT applications.
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فهرسة مساهمة: Keywords: CagA antigen; Helicobacter pylori; Tamm Plasmon Polariton; diagnostics; high sensitivity; optical biosensor; porous silicon; specificity
المشرفين على المادة: Z4152N8IUI (Silicon)
0 (Antigens, Bacterial)
0 (Bacterial Proteins)
0 (cagA protein, Helicobacter pylori)
تواريخ الأحداث: Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240903
رمز التحديث: 20240903
مُعرف محوري في PubMed: PMC11360118
DOI: 10.3390/s24165153
PMID: 39204849
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8220
DOI:10.3390/s24165153