دورية أكاديمية
أعرض في EDS

Breathing patterns during sleep and their relationship with FEV1 in pediatric patients with cystic fibrosis residing at high altitude.

التفاصيل البيبلوغرافية
العنوان: Breathing patterns during sleep and their relationship with FEV1 in pediatric patients with cystic fibrosis residing at high altitude.
المؤلفون: Duenas-Meza E; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Proaños-Jurado NJ; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Pulido-Fentanes S; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia., Severiche-Bueno DF; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Escamilla-Gil MI; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Bazurto-Zapata MA; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia., Jurado JL; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia., Suarez MR; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Giraldo-Cadavid LF; Departamento de investigación CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia.; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia.
المصدر: Frontiers in pediatrics [Front Pediatr] 2024 Aug 15; Vol. 12, pp. 1360227. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA, [2013]-
مستخلص: Introduction: Sleep-disordered breathing (SDB) and gas exchange disorders are common in patients with cystic fibrosis (CF). Currently, the impact of the disease on sleep patterns in patients living at high altitude and the relationship of these patterns to lung function are largely unknown. The aim of this study was to determine the frequency of SDB in children with CF aged 6-18 years and the relationship between SDB and lung function (FEV1).
Methods: This is an analytical cross-sectional study of children aged 6-18 years diagnosed with CF. Spirometry before and after bronchodilators and polysomnography with capnography were performed. Descriptive analysis of qualitative and continuous variables was performed. Spearman's correlation coefficient was used to determine the correlation between polysomnogram and lung function (FEV1).
Results: Twenty-four patients with CF were included. The mean age was 10.5 ± 3.1 years and 62.5% were male. Nine children had bronchiectasis on chest CT. The median absolute baseline FEV 1 was 1,880 (1,355-2,325) ml and 98% (83%-110%) of predicted value. No significant difference in FEV 1 % was observed between subjects with obstructive sleep apnea (OSA) and those without OSA ( P  = 0.56). The prevalence of OSA was 66.7% in children younger than 13 years and 40% in children older than 13 years. The Spearman correlation coefficient between FEV 1 and percentage of total sleep time with saturation less than 90% (T90) was rho -0.52 ( p -value = 0.018), and between FEV1 and percentage of total sleep time with saturation less than 85% (T85) was statistically significant with rho -0.45 ( p -value = 0.041). A positive correlation was observed between FEV 1 and SpO 2 during sleep with rho 0.53 and a statistically significant p -value (0.014).
Conclusions: A high prevalence of sleep apnea was found in children with CF living at high altitude, with a negative correlation between FEV 1 and T90 and T85 oxygenation indices, and a positive correlation between FEV 1 and SpO2 during sleep.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2024 Duenas-Meza, Proaños-Jurado, Pulido-Fentanes, Severiche-Bueno, Escamilla-Gil, Bazurto-Zapata, Jurado, Suarez and Giraldo-Cadavid.)
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فهرسة مساهمة: Keywords: cystic fibrosis; high altitude; obstructive sleep apnea; sleep; sleep disorder breathing (SDB)
تواريخ الأحداث: Date Created: 20240830 Latest Revision: 20240903
رمز التحديث: 20240903
مُعرف محوري في PubMed: PMC11357949
DOI: 10.3389/fped.2024.1360227
PMID: 39210986
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-2360
DOI:10.3389/fped.2024.1360227