دورية أكاديمية
Low Thyroid Hormones Level Attenuates Mitochondrial Dysfunction and Right Ventricular Failure in Pulmonary Hypertensive Rats.
| العنوان: | Low Thyroid Hormones Level Attenuates Mitochondrial Dysfunction and Right Ventricular Failure in Pulmonary Hypertensive Rats. |
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| المؤلفون: | Souza NSC; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil., Barenco-Marins T; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil., Ferraz AP; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil., Barbosa RAQ; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil., Maciel L; Campus Professor Geraldo Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, Brazil., Ponte CG; Instituto Federal de Educação, Ciências E Tecnologia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Seara FAC; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil. searafac@biof.ufrj.br., Olivares EL; Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.; Sociedade Brasileira de Fisiologia, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, São Paulo, Brazil., Nascimento JHM; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 373 Carlos Chagas Filho Avenue, Rio de Janeiro, Brazil. |
| المصدر: | Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Norwell Ma : Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Original Publication: [Norwell, MA] : Martinus Nijhoff Pub., [c1987- |
| مستخلص: | Purpose: This study is to investigate the repercussions of hypothyroidism in the pathophysiological progression of pulmonary arterial hypertension (PAH). Methods: While the control (CTL, n = 5) male Wistar rats received vehicle, PAH was induced with monocrotaline (MCT group, n = 15). Hypothyroidism was induced in a subset of rats by methimazole 3 weeks prior to the MCT injection (MMZ + MCT group, n = 15). Plasma thyroid hormones were measured by radioimmunoassay. Electrocardiographic, echocardiographic, and hemodynamic analyses were performed to evaluate the progression of PAH. Gene expression of antioxidant enzymes and cardiac hypertrophy markers were assessed by qPCR. Mitochondrial respiration, ATP levels, and ROS production were measured in right ventricular (RV) samples. Results: Plasma T3 and T4 decreased in both MCT and MMZ + MCT groups (p < 0.05). Right ventricular systolic pressure (RVSP) increased, and RV - dP/dt, + dP/dt, and contractility index decreased in the MCT versus the CTL group and remained within control levels in the MMZ + MCT group (p < 0.05). Relative RV weight, RV wall thickness, RV diastolic area, and relative lung weight were augmented in the MCT versus the CTL group, whereas all parameters were improved to the CTL levels in the MMZ + MCT group (p < 0.05). Only the MCT group exhibited an increased duration of QTc interval compared to the baseline period (p < 0.05). ADP-induced mitochondrial respiration and ATP levels were decreased, and ROS production was increased in MCT versus the CTL group (p < 0.05), while the MMZ + MCT group exhibited increased mitochondrial respiration versus the MCT group (p < 0.05). Conclusion: Hypothyroidism attenuated the RV mitochondrial dysfunction and the pathophysiological progression of MCT-induced PAH. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Heart failure; Mitochondria; Pulmonary hypertension; Thyroid hormones |
| تواريخ الأحداث: | Date Created: 20240831 Latest Revision: 20240831 |
| رمز التحديث: | 20240902 |
| DOI: | 10.1007/s10557-024-07618-5 |
| PMID: | 39215901 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-7241 |
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| DOI: | 10.1007/s10557-024-07618-5 |