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Mechanistic insights and knowledge gaps in the effects of radiation therapy on cardiac arrhythmias.

التفاصيل البيبلوغرافية
العنوان: Mechanistic insights and knowledge gaps in the effects of radiation therapy on cardiac arrhythmias.
المؤلفون: Balaji P; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia., Liulu X; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia., Sivakumar S; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia., Chong JJH; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Centre for Heart Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia., Kizana E; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Centre for Heart Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia., Vandenberg JI; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia., Hill AP; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia., Hau E; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Radiation Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, NSW, Westmead, Australia; Blacktown Hematology and Cancer Centre, Blacktown Hospital, NSW, Blacktown, Australia., Qian PC; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address: pierre.qian@sydney.edu.au.
المصدر: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31.
Publication Model: Ahead of Print
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier, Inc
Original Publication: Elmsford, N. Y., Pergamon Press.
مستخلص: Stereotactic body radiation therapy (SBRT) is an innovative modality for treatment of refractory ventricular arrhythmias (VA). Phase I/II clinical trials have demonstrated the remarkable efficacy of SBRT at reducing VA burden(by>85%) in patients with good short-term safety. SBRT as an option for VA treatment delivered in an ambulatory, non-sedated patient in a single fraction, during an outpatient session of 15-30 minutes, without added risks of anesthetic or surgery is clinically relevant. However, the underlying mechanism remains unclear. Currently used clinical dosing of SBRT has been derived from preclinical studies aimed to induce transmural fibrosis in the atria. The propitious clinical effects of SBRT appear earlier than the time-course for fibrosis. This review addresses the plausible mechanisms by which radiation alters the electrophysiological properties of myocytes and myocardial conduction to impart an anti-arrhythmic effect to elucidate clinical observations and point the direction for further research in this promising area.
Competing Interests: Declaration of competing interest None
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: arrhythmias; cardiac; mechanisms; radiation; treatment
تواريخ الأحداث: Date Created: 20240902 Latest Revision: 20240902
رمز التحديث: 20240903
DOI: 10.1016/j.ijrobp.2024.08.040
PMID: 39222823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-355X
DOI:10.1016/j.ijrobp.2024.08.040