دورية أكاديمية
Pharmacokinetics and haemodynamic effects of tocainide in patients with acute myocardial infarction complicated by left ventricular failure.
| العنوان: | Pharmacokinetics and haemodynamic effects of tocainide in patients with acute myocardial infarction complicated by left ventricular failure. |
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| المؤلفون: | MacMahon B, Bakshi M, Branagan P, Kelly JG, Walsh MJ |
| المصدر: | British journal of clinical pharmacology [Br J Clin Pharmacol] 1985 Apr; Vol. 19 (4), pp. 429-34. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Print ISSN: 0306-5251 (Print) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: London, Macmillan Journals Ltd. |
| مواضيع طبية MeSH: | Anti-Arrhythmia Agents/*pharmacology , Heart Failure/*physiopathology , Hemodynamics/*drug effects , Lidocaine/*analogs & derivatives , Myocardial Infarction/*physiopathology, Aged ; Anti-Arrhythmia Agents/metabolism ; Blood Pressure/drug effects ; Cardiac Output/drug effects ; Chromatography, Gas ; Creatine Kinase/metabolism ; Electrocardiography ; Female ; Half-Life ; Heart Failure/complications ; Heart Rate/drug effects ; Humans ; Kinetics ; Lidocaine/metabolism ; Lidocaine/pharmacology ; Male ; Middle Aged ; Myocardial Infarction/complications ; Stroke Volume/drug effects ; Time Factors ; Tocainide |
| مستخلص: | The pharmacokinetics and haemodynamic effects of tocainide, an orally active structural analogue of lignocaine, were studied in patients with acute myocardial infarction complicated by left ventricular failure. Fourteen patients (mean age 65 years) with acute myocardial infarction complicated by mild left ventricular failure were studied, following a single dose of tocainide (250 mg) by intravenous infusion, over 30 min. Heart rate, systemic arterial pressure, pulmonary artery pressure and cardiac output were monitored. Plasma tocainide levels were estimated by gas chromatography. The mean plasma level of tocainide achieved was 2.95 micrograms/ml (15.37 mmol/l). The mean plasma half-life was 15.6 h. The mean cardiac index was reduced 5 min after completion of the infusion, from 2.24 1 min-1 m-2 (+/- 0.40) to 2.07 1 min-1 m-2 (+/- 0.29) (P less than 0.01). At 90 min the cardiac index had returned to pre-treatment levels. Small changes were seen in the heart rate, arterial blood pressure and the pulmonary artery pressure but these changes were not statistically significant. The pharmacokinetics of tocainide were not significantly altered in patients with acute myocardial infarction complicated by mild left ventricular failure. |
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| المشرفين على المادة: | 0 (Anti-Arrhythmia Agents) 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) EC 2.7.3.2 (Creatine Kinase) |
| تواريخ الأحداث: | Date Created: 19850401 Date Completed: 19850711 Latest Revision: 20190511 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC1463818 |
| DOI: | 10.1111/j.1365-2125.1985.tb02666.x |
| PMID: | 3922392 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-5251 |
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| DOI: | 10.1111/j.1365-2125.1985.tb02666.x |