دورية أكاديمية
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Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells.

التفاصيل البيبلوغرافية
العنوان: Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells.
المؤلفون: Jia K; Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, China., Luo X; Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, China.; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Yi J; Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, China. jingyany@swmu.edu.cn., Zhang C; Department of Cardiology, The Affiliated Hospital, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, China. zhangchx999@163.com.
المصدر: Biological research [Biol Res] 2024 Sep 04; Vol. 57 (1), pp. 61. Date of Electronic Publication: 2024 Sep 04.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Biomed Central, Ltd Country of Publication: England NLM ID: 9308271 Publication Model: Electronic Cited Medium: Internet ISSN: 0717-6287 (Electronic) Linking ISSN: 07169760 NLM ISO Abbreviation: Biol Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : London : Biomed Central, Ltd
Original Publication: Santiago : Society of Biology of Chile, [1992-
مواضيع طبية MeSH: Muscle, Smooth, Vascular* , Gonadal Steroid Hormones*/physiology , Gonadal Steroid Hormones*/pharmacology , Myocytes, Smooth Muscle*/physiology , Myocytes, Smooth Muscle*/drug effects , Myocytes, Smooth Muscle*/metabolism, Humans ; Animals ; Phenotype ; Signal Transduction/physiology
مستخلص: Sex hormones play a pivotal role as endocrine hormones that exert profound effects on the biological characteristics and vascular function of vascular smooth muscle cells (VSMCs). By modulating intracellular signaling pathways, activating nuclear receptors, and regulating gene expression, sex hormones intricately influence the morphology, function, and physiological state of VSMCs, thereby impacting the biological properties of vascular contraction, relaxation, and growth. Increasing evidence suggests that abnormal phenotypic changes in VSMCs contribute to the initiation of vascular diseases, including atherosclerosis. Therefore, understanding the factors governing phenotypic alterations in VSMCs and elucidating the underlying mechanisms can provide crucial insights for refining interventions targeted at vascular diseases. Additionally, the varying levels of different types of sex hormones in the human body, influenced by sex and age, may also affect the phenotypic conversion of VSMCs. This review aims to explore the influence of sex hormones on the phenotypic switching of VSMCs and the development of associated vascular diseases in the human body.
(© 2024. The Author(s).)
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معلومات مُعتمدة: U23A20398, 82030007 National Natural Science Foundation of China; 82301845 National Natural Science Foundation of China; 2023M732929 China Postdoctoral Science Foundation
فهرسة مساهمة: Keywords: Diseases; Phenotypic switching; Sex hormones; Vascular smooth muscle cells
المشرفين على المادة: 0 (Gonadal Steroid Hormones)
تواريخ الأحداث: Date Created: 20240903 Date Completed: 20240904 Latest Revision: 20240903
رمز التحديث: 20240904
DOI: 10.1186/s40659-024-00542-w
PMID: 39227995
قاعدة البيانات: MEDLINE
الوصف
تدمد:0717-6287
DOI:10.1186/s40659-024-00542-w