دورية أكاديمية
Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity.
| العنوان: | Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity. |
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| المؤلفون: | Křoustková J, Kohelová E, Muthná D; Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, 500 03 Hradec Králové, Czech Republic., Kuneš J, Havelek R; Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, 500 03 Hradec Králové, Czech Republic., Vrabec R, Malaník M; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, 61200 Brno, Czech Republic., Suchánková D, Chlebek J, Jenčo J, Kosturko Š, Cahlíková L |
| المصدر: | Journal of natural products [J Nat Prod] 2024 Sep 27; Vol. 87 (9), pp. 2317-2326. Date of Electronic Publication: 2024 Sep 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Amaryllidaceae Alkaloids*/pharmacology , Amaryllidaceae Alkaloids*/chemistry , Amaryllidaceae Alkaloids*/isolation & purification , Amaryllidaceae*/chemistry, Humans ; Molecular Structure ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Drug Screening Assays, Antitumor ; Phenanthridines/pharmacology ; Phenanthridines/chemistry |
| مستخلص: | This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine ( 1 ) and 6-oxonarcissidine ( 2 ), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid-base conditions yielded the unreported isolation artifacts 3 and 4 . This work also provides analytical data for alkaloids not properly described in the literature ( 5 and 6 ). The hippeastidine/zephyranine scaffolds in derivatives 3 , 4 , and 8 - 10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine ( 12 ), haemanthidine ( 13 ), and lycorine ( 27 ) showed significant cell growth inhibition. |
| المشرفين على المادة: | 0 (Amaryllidaceae Alkaloids) 0 (Antineoplastic Agents, Phytogenic) 0 (Phenanthridines) 466-75-1 (hemanthamine) I9Q105R5BU (lycorine) |
| تواريخ الأحداث: | Date Created: 20240904 Date Completed: 20240927 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1021/acs.jnatprod.4c00825 |
| PMID: | 39229678 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/acs.jnatprod.4c00825 |