دورية أكاديمية
أعرض في EDS

Isolated perfused rabbit lung as a model to study the absorption of organic aerosols.

التفاصيل البيبلوغرافية
العنوان: Isolated perfused rabbit lung as a model to study the absorption of organic aerosols.
المؤلفون: French MC, Wishart GN
المصدر: Journal of pharmacological methods [J Pharmacol Methods] 1985 Jun; Vol. 13 (3), pp. 241-8.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/north-Holland Country of Publication: United States NLM ID: 7806596 Publication Model: Print Cited Medium: Print ISSN: 0160-5402 (Print) Linking ISSN: 01605402 NLM ISO Abbreviation: J Pharmacol Methods Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Elsevier/north-Holland
Original Publication: New York, Elsevier/North-Holland.
مواضيع طبية MeSH: Aerosols/*metabolism , Lung/*physiology , Perfusion/*instrumentation, Absorption ; Anesthesia ; Animals ; Carbon Dioxide/blood ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Models, Biological ; Oxygen/blood ; Rabbits ; Respiration ; Tidal Volume
مستخلص: An improved technique for perfused lung preparations adapted for absorption studies with organic aerosols is described. The model developed by Niemeier and Bingham (1972) was modified to place greater emphasis on the respiratory functions of the lung as an index of viability. Perfusion of this preparation for 2 hr showed that tidal volume, pulmonary blood flow, and visual appearance were the most sensitive indicators of physiological change. The importance of relevant criteria for assessment of viability is discussed. In addition, a simple technique for on-line computerized measurement of tidal volume and respiratory frequency is described.
المشرفين على المادة: 0 (Aerosols)
142M471B3J (Carbon Dioxide)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 19850601 Date Completed: 19850725 Latest Revision: 20191030
رمز التحديث: 20221213
DOI: 10.1016/0160-5402(85)90024-5
PMID: 3923271
قاعدة البيانات: MEDLINE
الوصف
تدمد:0160-5402
DOI:10.1016/0160-5402(85)90024-5