دورية أكاديمية
Isolated perfused rabbit lung as a model to study the absorption of organic aerosols.
العنوان: | Isolated perfused rabbit lung as a model to study the absorption of organic aerosols. |
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المؤلفون: | French MC, Wishart GN |
المصدر: | Journal of pharmacological methods [J Pharmacol Methods] 1985 Jun; Vol. 13 (3), pp. 241-8. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier/north-Holland Country of Publication: United States NLM ID: 7806596 Publication Model: Print Cited Medium: Print ISSN: 0160-5402 (Print) Linking ISSN: 01605402 NLM ISO Abbreviation: J Pharmacol Methods Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York Ny : Elsevier/north-Holland Original Publication: New York, Elsevier/North-Holland. |
مواضيع طبية MeSH: | Aerosols/*metabolism , Lung/*physiology , Perfusion/*instrumentation, Absorption ; Anesthesia ; Animals ; Carbon Dioxide/blood ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Models, Biological ; Oxygen/blood ; Rabbits ; Respiration ; Tidal Volume |
مستخلص: | An improved technique for perfused lung preparations adapted for absorption studies with organic aerosols is described. The model developed by Niemeier and Bingham (1972) was modified to place greater emphasis on the respiratory functions of the lung as an index of viability. Perfusion of this preparation for 2 hr showed that tidal volume, pulmonary blood flow, and visual appearance were the most sensitive indicators of physiological change. The importance of relevant criteria for assessment of viability is discussed. In addition, a simple technique for on-line computerized measurement of tidal volume and respiratory frequency is described. |
المشرفين على المادة: | 0 (Aerosols) 142M471B3J (Carbon Dioxide) S88TT14065 (Oxygen) |
تواريخ الأحداث: | Date Created: 19850601 Date Completed: 19850725 Latest Revision: 20191030 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/0160-5402(85)90024-5 |
PMID: | 3923271 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0160-5402 |
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DOI: | 10.1016/0160-5402(85)90024-5 |