دورية أكاديمية
أعرض في EDS

Abdominal obesity is associated with increased worsening renal function risk in patients with heart failure with preserved ejection fraction.

التفاصيل البيبلوغرافية
العنوان: Abdominal obesity is associated with increased worsening renal function risk in patients with heart failure with preserved ejection fraction.
المؤلفون: Zhang Q; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China., Tai S; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China., Zhou S; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. zhoushenghua@csu.edu.cn.
المصدر: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Sep 09; Vol. 24 (1), pp. 477. Date of Electronic Publication: 2024 Sep 09.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Obesity, Abdominal*/physiopathology , Obesity, Abdominal*/diagnosis , Obesity, Abdominal*/epidemiology , Heart Failure*/physiopathology , Heart Failure*/diagnosis , Heart Failure*/epidemiology , Stroke Volume* , Waist Circumference* , Body Mass Index* , Kidney*/physiopathology , Mineralocorticoid Receptor Antagonists*/therapeutic use, Humans ; Female ; Male ; Aged ; Risk Factors ; Middle Aged ; Risk Assessment ; Time Factors ; Disease Progression ; Creatinine/blood ; Ventricular Function, Left ; Prognosis ; Biomarkers/blood ; Aged, 80 and over ; Glomerular Filtration Rate
مستخلص: Background: Worsening renal function (WRF) is a frequent comorbidity of heart failure with preserved ejection fraction (HFpEF). However, its relationship with abdominal obesity in terms of HFpEF remains unclear. This study aimed to evaluate the value of waist circumference (WC) and body mass index (BMI) in predicting WRF and examine the correlation between abdominal obesity and the risk of WRF in the HFpEF population.
Methods: Data were obtained from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial. Abdominal obesity was defined as WC ≥ 102 cm for men and ≥ 88 cm for women. WRF was defined as doubling of serum creatinine concentration from baseline. Restricted cubic splines and receiver operating characteristic curves were used to evaluate the value of WC and BMI in predicting WRF. Cumulative incidence curves and cox proportional-hazards models were used to compare patients with and without abdominal obesity.
Results: We included 2,806 patients with HFpEF in our study (abdominal obesity, n: 2,065). Although baseline creatinine concentrations did not differ, patients with abdominal obesity had higher concentrations during a median follow-up time of 40.9 months. Unlike BMI, WC exhibited a steady linear association with WRF and was a superior WRF predictor. Patients with abdominal obesity exhibited a higher risk of WRF after multivariable adjustment (hazard ratio: 1.632; 95% confidence interval: 1.015-2.621; P: 0.043).
Conclusions: Abdominal obesity is associated with an increased risk of WRF in the HFpEF population.
Trial Registration: URL: https://beta.
Clinicaltrials: gov . Unique identifier: NCT00094302.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 82150006 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Abdominal obesity; Body fat distribution; Body mass index; HFpEF; Waist circumference; Worsening renal function
سلسلة جزيئية: ClinicalTrials.gov NCT00094302
المشرفين على المادة: 0 (Mineralocorticoid Receptor Antagonists)
AYI8EX34EU (Creatinine)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240909 Date Completed: 20240910 Latest Revision: 20240912
رمز التحديث: 20240912
مُعرف محوري في PubMed: PMC11382427
DOI: 10.1186/s12872-024-04118-0
PMID: 39251903
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2261
DOI:10.1186/s12872-024-04118-0