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A pragmatic randomized trial to examine the effect of combining healthy diet with mindfulness cognitive therapy to reduce depressive symptoms among university students in a low-resource setting: protocol for the NutriMind Project.

التفاصيل البيبلوغرافية
العنوان: A pragmatic randomized trial to examine the effect of combining healthy diet with mindfulness cognitive therapy to reduce depressive symptoms among university students in a low-resource setting: protocol for the NutriMind Project.
المؤلفون: Kardel KR; Department of Nutrition, IMB, University of Oslo, Oslo, Norway., Iversen PO; Department of Nutrition, IMB, University of Oslo, Oslo, Norway. p.o.iversen@medisin.uio.no.; Department of Haematology, Oslo University Hospital, Oslo, Norway. p.o.iversen@medisin.uio.no.; Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. p.o.iversen@medisin.uio.no., Kaaya AN; Department of Food Technology and Nutrition, Makerere University, Kampala, Uganda., Muhoozi G; Department of Family life and Consumer studies, Kyambogo University, Kampala, Uganda., Veierød MB; Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Wangen KR; Department of Health Management and Health Economics, Institute of Health and Society, University of Oslo, Oslo, Norway., Børøsund E; Department of Digital Health Research, Division of Medicine, Oslo University Hospital, Oslo, Norway., Friberg PA; Center for Crisis Psychology, University of Bergen, Bergen, Norway.
المصدر: BMC psychiatry [BMC Psychiatry] 2024 Sep 11; Vol. 24 (1), pp. 610. Date of Electronic Publication: 2024 Sep 11.
نوع المنشور: Journal Article; Clinical Trial Protocol; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Mindfulness*/methods , Depression*/therapy , Depression*/prevention & control , Depression*/psychology , Students*/psychology , Diet, Healthy*/methods , Diet, Healthy*/psychology, Humans ; Uganda ; Universities ; Male ; Female ; Young Adult ; Adult ; Combined Modality Therapy/methods ; Pragmatic Clinical Trials as Topic
مستخلص: Background: Mental health disorders still rank as leading causes of morbidity worldwide despite increasing awareness and improvements in treatment. Notably, low- and middle-income countries like Uganda, are disproportionately affected by such disorders. The burden of depressive symptoms in these countries is particularly high among students, aggravated by poverty, malnutrition, and inadequate public health governance, yet it is clearly under-researched, making it hard to achieve several of UN Sustainability Development Goals. Current treatment options are insufficient to tackle the increased burden of depressive disease. This is more challenging for low-resource regions especially in Sub-Saharan Africa, suggesting the need for alternative treatments that can swiftly be applied if proven effective. The main aim of this randomized controlled trial (RCT) is therefore to examine if a low-cost healthy diet (based on local Ugandan foods) combined with easy-to access mindfulness cognitive therapy can reduce depressive symptoms among university students in Uganda.
Methods: We will recruit female and male students at Makerere University, the largest public university in Uganda, to an open, intention-to-treat, two-armed RCT. Those who score above a predefined threshold on a self-reported assessment of depressive symptoms, measured by the Center for Epidemiological Studies - Depression score (CES-D), are eligible for study inclusion and will be randomized to either an intervention (n = 125) or a control (n = 125) group. The intervention group will receive educational group-based sessions on how to prepare a Mediterranean-type of healthy diet and how to adhere to the principles of mindfulness-based cognitive therapy. Outcome measures include self-reported depression symptoms, quality of life, and dietary intakes. In addition we will perform a cost-effectiveness analysis. The RCT intervention will last 9 months, followed by additional 15 months with regular data collections.
Discussion: We here describe a novel approach to treat depressive symptoms among university students living in resource constraint settings, by combining a healthy diet with low threshold psychotherapy. If this intervention succeeds, our project can be viewed as a step towards evidence-based behavior practices for young adults with a common mental disorder (depression) that are beneficial to public mental health initiatives and management.
Trial Registration: The RCT is registered in ClinicalTrials.gov (ID: NCT05848973). The date of registration was August 14, 2023.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Depression; Diet; Mental health; Mindfulness-based cognitive therapy (MBCT); Randomized trial; Uganda; University students
سلسلة جزيئية: ClinicalTrials.gov NCT05848973
تواريخ الأحداث: Date Created: 20240911 Date Completed: 20240912 Latest Revision: 20240914
رمز التحديث: 20240914
مُعرف محوري في PubMed: PMC11391632
DOI: 10.1186/s12888-024-06056-9
PMID: 39261786
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-244X
DOI:10.1186/s12888-024-06056-9