دورية أكاديمية
Clinical significance of TLR7/IL-23/IL-17 signaling pathway in patients with acute respiratory distress syndrome.
| العنوان: | Clinical significance of TLR7/IL-23/IL-17 signaling pathway in patients with acute respiratory distress syndrome. |
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| المؤلفون: | Chu L; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China., Liu F; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China., Tang K; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China. Electronic address: HYICU5158@126.com. |
| المصدر: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 Sep 11; Vol. 79, pp. 100358. Date of Electronic Publication: 2024 Sep 11 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]- |
| مواضيع طبية MeSH: | Respiratory Distress Syndrome*/blood , Respiratory Distress Syndrome*/genetics , Interleukin-17*/blood , Toll-Like Receptor 7*/genetics , Signal Transduction* , Interleukin-23*/blood, Humans ; Female ; Male ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Prognosis ; Case-Control Studies ; Severity of Illness Index ; RNA, Messenger/analysis ; Risk Factors ; Leukocytes, Mononuclear/metabolism ; Clinical Relevance |
| مستخلص: | Objectives: To analyze the clinical significance of Toll-Like Receptor 7/Interleukin-23/Interleukin-17 (TLR7/IL-23/IL-17) signaling pathway in patients with Acute Respiratory Distress Syndrome (ARDS). Method: The clinical data of 85 patients with ARDS were retrospectively analyzed and set as the ARDS group, and the clinical data of 85 healthy participants during the same period were set as the healthy control group. Univariate and multivariate logistic regression were used to analyze risk the factors affecting the prognosis of ARDS patients. Results: TheTLR7 mRNA expression and IL-23 and IL-17 levels in peripheral blood mononuclear cells were higher in the ARDS group than in the control group (p < 0.05). TLR7 mRNA expression, IL-23, IL-17, Surfactant Protein-D (SP-D), and Clara Cell protein-16 (CC-16) levels were the highest in the severe group, followed by the moderate group, and the lowest in the mild group, while Oxygenation Index (OI) was the lowest in the severe group, followed by the moderate group, and the highest in the mild group (p < 0.05). Multivariate logistic regression analysis found that the disease grade (severe), TLR7 mRNA expression, IL-23 level, and IL-17 level were the risk factors affecting the 28-d survival status of ARDS patients (OR > 1, p < 0.05). Conclusions: In ARDS patients, the TLR7/IL-23/IL-17 signaling pathway is activated. The expression of this pathway is closely related to the severity of the disease and the levels of lung injury markers, and it is a risk factor that may have a direct impact on the prognosis of ARDS patients. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Acute respiratory distress syndrome; Interleukin-17; Interleukin-23; Toll-like receptor 7 |
| المشرفين على المادة: | 0 (Interleukin-17) 0 (Toll-Like Receptor 7) 0 (Interleukin-23) 0 (RNA, Messenger) 0 (TLR7 protein, human) |
| تواريخ الأحداث: | Date Created: 20240912 Date Completed: 20240917 Latest Revision: 20240924 |
| رمز التحديث: | 20240924 |
| مُعرف محوري في PubMed: | PMC11416599 |
| DOI: | 10.1016/j.clinsp.2024.100358 |
| PMID: | 39265238 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1980-5322 |
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| DOI: | 10.1016/j.clinsp.2024.100358 |