دورية أكاديمية
Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia.
| العنوان: | Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia. |
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| المؤلفون: | Maimunah U; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Kholili U; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Vidyani A; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Sugihartono T; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Tanaya WM; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Wessels FI; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia., Alshawsh MA; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Miftahussurur M; Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.; Helicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia. |
| المصدر: | Narra J [Narra J] 2024 Aug; Vol. 4 (2), pp. e816. Date of Electronic Publication: 2024 Jun 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Narra Sains Indonesia Country of Publication: Indonesia NLM ID: 9918625888906676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2807-2618 (Electronic) Linking ISSN: 28072618 NLM ISO Abbreviation: Narra J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Banda Aceh, Indonesia : Narra Sains Indonesia, [2021]- |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , COVID-19*/blood , COVID-19*/complications , Severity of Illness Index* , Liver Function Tests*, Humans ; Male ; Female ; Retrospective Studies ; Indonesia/epidemiology ; Middle Aged ; Adult ; Liver Diseases/epidemiology ; SARS-CoV-2 ; HIV Infections/epidemiology ; Risk Factors |
| مستخلص: | Coronavirus disease 2019 (COVID-19) is characterized by an acute respiratory infection with multisystem involvement and the association of its severity to liver function abnormalities is not well characterized. The aim of this study was to assess the association between the severity of COVID-19 patients and liver function abnormalities. This retrospective study included adult patients with confirmed COVID-19, which were classified as non-severe or severe according to World Health Organization guidelines. Liver function test results were compared between the severity groups. A total of 339 patients were included of which 150 (44.25%) were severe cases. The male-to-female ratio was 0.9:1 and 3:2 in the non-severe and severe groups, respectively ( p =0.031). Aspartate aminotransferase (AST), alanine transaminase (ALT), and total bilirubin levels and acute liver injury (ALI) incidence were significantly higher in the severe group compared to non-severe group ( p <0.001, p <0.001, p =0.025, p =0.014, respectively). In contrast, albumin levels were significantly lower ( p =0.001). Multivariate analysis showed that ALI was significantly associated with human immunodeficiency virus (HIV) infection (odds ratio (OR): 5.275; 95% confidence interval (CI): 1.165-23.890, p =0.031), hemoglobin level (OR: 1.214; 95%CI: 1.083-1.361, p =0.001), and hypoalbuminemia (OR: 2.627; 95%CI: 1.283-5.379, p =0.008). Pre-existing liver diseases were present in 6.5% of patients. No significant differences were observed between the groups based on COVID-19 severity and ALI presence. Liver function test abnormalities, including ALI, are more prevalent in patients with severe COVID-19 infection. HIV infection, high hemoglobin levels, and hypoalbuminemia may be potential risk factors for ALI. Competing Interests: All the authors declare that there are no conflicts of interest. (© 2024 The Author(s).) |
| References: | Biochem J. 1990 Feb 1;265(3):621-36. (PMID: 1689567) Lancet Infect Dis. 2020 Apr;20(4):425-434. (PMID: 32105637) Open Forum Infect Dis. 2019 Nov 05;6(11):ofz467. (PMID: 31777757) Hepatology. 2020 Sep;72(3):807-817. (PMID: 32473607) Liver Int. 2021 Jan;41(1):20-32. (PMID: 33190346) Clin Exp Hepatol. 2021 Sep;7(3):297-304. (PMID: 34712832) J Hepatol. 2020 Sep;73(3):566-574. (PMID: 32298767) Hepatol Int. 2020 Sep;14(5):690-700. (PMID: 32623632) Cytokine Growth Factor Rev. 2020 Aug;54:62-75. (PMID: 32513566) Front Endocrinol (Lausanne). 2021 Nov 02;12:741248. (PMID: 34795637) Indian J Med Microbiol. 2018 Apr-Jun;36(2):201-206. (PMID: 30084411) Ann Hepatol. 2020 Nov - Dec;19(6):592-596. (PMID: 32858226) N Engl J Med. 2020 Aug 6;383(6):590-592. (PMID: 32402155) JPEN J Parenter Enteral Nutr. 2019 Feb;43(2):181-193. (PMID: 30288759) Narra J. 2023 Apr;3(1):e102. (PMID: 38450034) Diabetes Care. 2021 Jan;44(1):50-57. (PMID: 33097559) N Engl J Med. 2020 Apr 30;382(18):1708-1720. (PMID: 32109013) J Leukoc Biol. 2020 Jul;108(1):17-41. (PMID: 32534467) Diabetes. 2007 May;56(5):1189-97. (PMID: 17322478) World J Gastroenterol. 2020 Aug 28;26(32):4753-4762. (PMID: 32921955) Sultan Qaboos Univ Med J. 2016 May;16(2):e132-41. (PMID: 27226903) Infect Dis Rep. 2022 Apr 20;14(3):278-286. (PMID: 35645213) Gastroenterology. 2020 Aug;159(2):768-771.e3. (PMID: 32376408) Diabetes Metab Syndr. 2020 Nov-Dec;14(6):1951-1954. (PMID: 33039937) Biochem Biophys Res Commun. 2020 May 21;526(1):135-140. (PMID: 32199615) Gut. 2005 Dec;54(12):1790-6. (PMID: 16166274) Hepatol Int. 2020 Sep;14(5):711-722. (PMID: 32623633) Thromb Res. 2020 Jul;191:145-147. (PMID: 32291094) Clin Gastroenterol Hepatol. 2020 Jun;18(7):1561-1566. (PMID: 32283325) J Hepatol. 2020 Aug;73(2):455-458. (PMID: 32305291) J Thromb Thrombolysis. 2021 Feb;51(2):313-329. (PMID: 32676883) Pharmacotherapy. 2002 Sep;22(9):1091-6. (PMID: 12222543) Liver Int. 2020 Jun;40(6):1321-1326. (PMID: 32239591) Narra J. 2022 Dec;2(3):e92. (PMID: 38449903) J Clin Med. 2022 Jan 08;11(2):. (PMID: 35054003) Hepatol Commun. 2020 Dec 10;5(2):177-188. (PMID: 33230491) Cell. 2020 Apr 16;181(2):271-280.e8. (PMID: 32142651) Front Immunol. 2020 May 19;11:1021. (PMID: 32574259) Steroids. 2008 May;73(5):495-501. (PMID: 18291430) Liver Int. 2020 Jun;40(6):1316-1320. (PMID: 32329563) |
| فهرسة مساهمة: | Keywords: Acute liver injury; COVID-19; disease severity; liver function abnormality; risk factors |
| تواريخ الأحداث: | Date Created: 20240916 Date Completed: 20240916 Latest Revision: 20240919 |
| رمز التحديث: | 20240920 |
| مُعرف محوري في PubMed: | PMC11391993 |
| DOI: | 10.52225/narra.v4i2.816 |
| PMID: | 39280282 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2807-2618 |
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| DOI: | 10.52225/narra.v4i2.816 |