دورية أكاديمية
Dose-response of epidural ropivacaine with 0.4 μg mL-1 of dexmedetomidine for labor analgesia: A prospective double-blinded study.
| العنوان: | Dose-response of epidural ropivacaine with 0.4 μg mL-1 of dexmedetomidine for labor analgesia: A prospective double-blinded study. |
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| المؤلفون: | Yin J; Department of Anesthesia, Women and Children Hospital of Jiashan, Jiaxing, China., Cao S; Department of Anesthesia, Women and Children Hospital of Jiashan, Jiaxing, China., Lei J; Department of Anesthesia, Women and Children Hospital of Jiashan, Jiaxing, China., Wang XY; Department of Anesthesia, Women and Children Hospital of Jiashan, Jiaxing, China., You JP; Department of Anesthesia, Women and Children Hospital of Jiashan, Jiaxing, China., Xu DC; Department of Anesthesia, The First People's Hospital of Jiashan, Jiaxing, China., Chen XD; Department of Anesthesia, The First People's Hospital of Jiashan, Jiaxing, China., Xu WP; Department of Anesthesia, The First People's Hospital of Pinghu, Zhejiang, China. |
| المصدر: | Medicine [Medicine (Baltimore)] 2024 Sep 20; Vol. 103 (38), pp. e39654. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| مواضيع طبية MeSH: | Ropivacaine*/administration & dosage , Dexmedetomidine*/administration & dosage , Analgesia, Epidural*/methods , Anesthetics, Local*/administration & dosage , Dose-Response Relationship, Drug* , Analgesia, Obstetrical*/methods, Humans ; Female ; Pregnancy ; Double-Blind Method ; Adult ; Prospective Studies ; Analgesics, Non-Narcotic/administration & dosage ; Pain Measurement ; Labor Pain/drug therapy ; Young Adult |
| مستخلص: | Background: Studies have shown that the ideal dose of epidural dexmedetomidine is 0.4 μg mL-1 for epidural labor analgesia. However, the appropriate dose of ropivacaine when combined with 0.4 μg mL-1 of dexmedetomidine for epidural labor analgesia is still unknown. Therefore, we aimed to determine the dose-response of ropivacaine when using 0.4 μg mL-1 of dexmedetomidine as epidural adjuvant for labor analgesia. Methods: One hundred of nulliparous singleton pregnant patients were randomized allocated into 1 of 5 groups with epidural ropivacaine concentration of 0.05%, 0.0625%, 0.075%, 0.0875%, and 0.1%. Labor analgesia was initialed with 12 mL of the mixed study solution. Effective analgesia was defined as a visual analogue scale <10 mm 30 minutes after the initial epidural bolus. The EC50 and EC95 for epidural ropivacaine was calculated by probit regression. Results: Ninety-three of parturients were involved into the final analysis. Totals of 63.2% (12/19), 73.7% (14/19), 88.9% (16/18), 94.7% (18/19), and 100% (18/18) of parturients in group 0.05, 0.0625, 0.075, 0.0875, and 0.1 received effective epidural labor analgesia. The calculated EC50 and EC95 of epidural ropivacaine were 0.046% (95% CI 0.028-0.054%) and 0.086% (95% CI 0.074-0.137%), respectively. Conclusions: Under the condition of the study, a bolus of 12 mL ropivacaine 0.086% and dexmedetomidine 0.4 μg mL-1 could afford 95% of nulliparous singleton pregnant patients without suffering labor pain after a test dose of lidocaine 45 mg. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.) |
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| المشرفين على المادة: | 7IO5LYA57N (Ropivacaine) 67VB76HONO (Dexmedetomidine) 0 (Anesthetics, Local) 0 (Analgesics, Non-Narcotic) |
| تواريخ الأحداث: | Date Created: 20240923 Date Completed: 20240923 Latest Revision: 20240926 |
| رمز التحديث: | 20240926 |
| مُعرف محوري في PubMed: | PMC11419513 |
| DOI: | 10.1097/MD.0000000000039654 |
| PMID: | 39312321 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-5964 |
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| DOI: | 10.1097/MD.0000000000039654 |