دورية أكاديمية
أعرض في EDS

Frailty is independently associated with subclinical cardiovascular disease in patients with systemic lupus erythematosus.

التفاصيل البيبلوغرافية
العنوان: Frailty is independently associated with subclinical cardiovascular disease in patients with systemic lupus erythematosus.
المؤلفون: Pappa M; National and Kapodistrian University of Athens Medical School, Athens, Greece., Keramiotou K; National and Kapodistrian University of Athens Faculty of Medicine, Athens, Greece., Sfikakis PP; 1st Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tektonidou MG; Rheumatology Unit, First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Athens, Attica, Greece mtektonidou@gmail.com.
المصدر: RMD open [RMD Open] 2024 Sep 23; Vol. 10 (3). Date of Electronic Publication: 2024 Sep 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Publishing Group, [2015]-
مواضيع طبية MeSH: Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/epidemiology , Frailty*/epidemiology , Frailty*/complications , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/epidemiology, Humans ; Female ; Male ; Middle Aged ; Cross-Sectional Studies ; Adult ; Risk Factors ; Plaque, Atherosclerotic/epidemiology ; Risk Assessment
مستخلص: Objectives: Cardiovascular disease is a leading cause of mortality in systemic lupus erythematosus (SLE). Frailty has been associated with an increased cardiovascular disease risk (CVR) in the general population. We aimed to examine the association between frailty and subclinical cardiovascular disease in patients with SLE.
Methods: In this cross-sectional study, we included all patients with SLE who underwent carotid/femoral artery ultrasound in our unit between 2016 and 2018. Clinical and laboratory data were collected at the time of ultrasound testing. Frailty was measured using the Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI). CVR (low, moderate, high, very high) was evaluated by the Systematic COronary Risk Evaluation (SCORE) model. Determinants of atherosclerotic plaque presence were assessed by logistic regression analyses, adjusting for potential confounders.
Results: 202 patients were included in the study. Atherosclerotic plaques (20.8% carotid, 17.3% femoral) were observed in 52/202 (25.7%) patients (89.1% women, mean (±SD) age 46.7±12.6). Median (IQR) SLICC-FI was 0.08 (0.04-0.10). 39 (19.3%) patients were classified as robust, 91 (45%) as relatively less fit, 59 (29.2%) as least fit and 13 (6.4%) as frail. In univariate analysis, plaque presence was significantly associated with age, disease duration, smoking, hypertension, systolic blood pressure, dyslipidaemia, SCORE, CVR class and SLICC-FI. CVR class (OR 5.16, p=0.000) and SLICC-FI (OR 1.34, p=0.03 per 0.05 point increase) remained significant in multivariate analysis after adjustment for traditional and disease-related CVR factors.
Conclusions: SLICC-FI is independently associated with plaque presence. Further studies are warranted to determine whether frailty-specific interventions can reduce CVR in patients with SLE.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: Atherosclerosis; Cardiovascular Diseases; Lupus Erythematosus, Systemic
تواريخ الأحداث: Date Created: 20240923 Date Completed: 20240924 Latest Revision: 20240925
رمز التحديث: 20240925
مُعرف محوري في PubMed: PMC11418478
DOI: 10.1136/rmdopen-2024-004527
PMID: 39313303
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-5933
DOI:10.1136/rmdopen-2024-004527