دورية أكاديمية
The association of common autoimmune diseases with autoimmune thyroiditis: a two-sample Mendelian randomization study.
| العنوان: | The association of common autoimmune diseases with autoimmune thyroiditis: a two-sample Mendelian randomization study. |
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| المؤلفون: | Zhang K; Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Luo Z; Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Wang X; Department of Rheumatology, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Sep 09; Vol. 15, pp. 1383221. Date of Electronic Publication: 2024 Sep 09 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Mendelian Randomization Analysis* , Thyroiditis, Autoimmune*/genetics , Thyroiditis, Autoimmune*/epidemiology , Thyroiditis, Autoimmune*/complications , Genome-Wide Association Study* , Autoimmune Diseases*/genetics , Autoimmune Diseases*/epidemiology , Autoimmune Diseases*/complications, Humans ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/epidemiology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/epidemiology ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide |
| مستخلص: | Objective: Numerous observational and retrospective studies have demonstrated an association between Autoimmune Thyroiditis (AIT) and various systemic Autoimmune Diseases (AIDs). However, the causal relationship between them remains uncertain. This study aims to investigate the causal link between AIT and diverse types of AIDs utilizing the Mendelian Randomization (MR) method. Method: We assessed the causal relationship between AIT and eight prevalent AIDs. Summary statistics from genome-wide association studies (GWAS) were sourced from the FinnGen biobank and IEU Open GWAS database. Two-sample MR analyses were conducted, with the primary statistical approach being the Inverse Variance Weighting (IVW) method. This was complemented by a series of sensitivity analyses, and the robustness of the findings was evaluated through the estimation of heterogeneity and pleiotropy. Results: When AIT was considered as the outcome, MR evidence suggested an association between Rheumatoid arthritis (RA), Type 1 diabetes (T1D), and Systemic lupus erythematosus (SLE) with AIT. Utilizing the Inverse Variance Weighting (IVW) method, we observed an increased risk of AIT with exposure to RA ( P = 0.024, OR=1.25; 95% CI = 1.03, 1.52), T1D ( P < 0.001, OR=1.27 95% CI = 1.11,1.46), and SLE ( P = 0.037, OR=1.14; 95% CI = 1.04,1.26). Conversely, no significant genetic causal relationship with AIT was found for Sjögren's syndrome (SS), Ankylosing Spondylitis (AS), Multiple sclerosis (MS), Crohn's disease (CD), and Ulcerative colitis (UC). Conclusion: This study identified RA, T1D, and SLE as triggering factors for AIT. The incidence rate of AIT in patients with RA, T1D, and SLE may be higher than that in the general population. Therefore, individuals with these three diseases should undergo regular monitoring of thyroid-related indicators. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Zhang, Luo and Wang.) |
| References: | Cell. 2014 Jun 19;157(7):1577-90. (PMID: 24949970) Eur Rev Med Pharmacol Sci. 2023 Dec;27(24):12051-12057. (PMID: 38164867) Endocrine. 2015 Sep;50(1):79-86. (PMID: 25645464) Mult Scler Relat Disord. 2023 Oct;78:104903. (PMID: 37556937) Ann N Y Acad Sci. 2009 Sep;1173:211-6. (PMID: 19758153) Diabetes Metab Res Rev. 2011 Nov;27(8):867-71. (PMID: 22069275) Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298) Best Pract Res Clin Endocrinol Metab. 2023 Mar;37(2):101773. (PMID: 36907786) J Diabetes Complications. 2016 Apr;30(3):420-5. (PMID: 26868720) Eur J Epidemiol. 2017 May;32(5):377-389. (PMID: 28527048) J Immunol Res. 2021 Aug 28;2021:8263829. (PMID: 34493981) Mediators Inflamm. 2017;2017:3916395. (PMID: 28133421) Cells. 2021 Jan 30;10(2):. (PMID: 33573252) Front Immunol. 2022 May 26;13:879824. (PMID: 35720300) Arthritis Res Ther. 2010;12(5):R174. (PMID: 20849588) Am J Med Sci. 2018 Oct;356(4):344-349. (PMID: 30360802) Rheumatology (Oxford). 2021 Jul 1;60(7):3088-3098. (PMID: 30770920) Front Immunol. 2022 Jan 26;13:804401. (PMID: 35154120) Int J Epidemiol. 2017 Dec 1;46(6):1985-1998. (PMID: 29040600) Best Pract Res Clin Endocrinol Metab. 2019 Dec;33(6):101372. (PMID: 31932147) Arthritis Rheumatol. 2019 Apr;71(4):486-495. (PMID: 30507064) Elife. 2018 May 30;7:. (PMID: 29846171) BMC Endocr Disord. 2023 Oct 5;23(1):212. (PMID: 37798692) Diabetes Metab Syndr. 2019 Jan - Feb;13(1):608-611. (PMID: 30641774) Front Immunol. 2021 Jul 09;12:686155. (PMID: 34305919) J Rheumatol. 2013 Sep;40(9):1535-44. (PMID: 23858047) Clin Rev Allergy Immunol. 2019 Jun;56(3):362-374. (PMID: 30187363) Ann Rheum Dis. 2009 Apr;68(4):579-83. (PMID: 18434448) Clin Rheumatol. 2014 Jul;33(7):955-61. (PMID: 24384825) Diabetes Care. 2015 Oct;38 Suppl 2:S21-8. (PMID: 26405068) J Biol Chem. 2016 Feb 19;291(8):4079-90. (PMID: 26703475) J Neuroimmunol. 2023 Dec 15;385:578226. (PMID: 37918214) Front Immunol. 2022 Oct 06;13:999108. (PMID: 36275658) Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253) Nat Genet. 2018 May;50(5):693-698. (PMID: 29686387) Front Immunol. 2022 Sep 23;13:996469. (PMID: 36211343) Nat Rev Endocrinol. 2018 May;14(5):301-316. (PMID: 29569622) Nat Rev Rheumatol. 2023 Jun;19(6):331-342. (PMID: 37041269) Int J Mol Sci. 2014 Jul 11;15(7):12280-93. (PMID: 25019342) J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):265-72. (PMID: 26122213) Autoimmunity. 2014 Nov;47(7):459-65. (PMID: 24798189) Diabetes Metab J. 2021 Nov;45(6):899-908. (PMID: 34225445) J Autoimmun. 2019 Jul;101:121-130. (PMID: 31030958) Autoimmun Rev. 2020 Oct;19(10):102649. (PMID: 32805423) Semin Immunol. 2021 Mar;53:101528. (PMID: 34810089) J Immunol Res. 2018 Oct 3;2018:3491269. (PMID: 30402506) Intest Res. 2017 Apr;15(2):255-259. (PMID: 28522958) Bioinformatics. 2016 Oct 15;32(20):3207-3209. (PMID: 27318201) Immunology. 2017 Oct;152(2):243-254. (PMID: 28542921) J Clin Rheumatol. 2022 Jan 1;28(1):e38-e43. (PMID: 32956154) Heliyon. 2022 Nov 21;8(11):e11680. (PMID: 36439744) Cold Spring Harb Perspect Med. 2022 May 17;12(4):. (PMID: 34872952) Autoimmun Rev. 2020 Jun;19(6):102529. (PMID: 32234405) Rheumatol Int. 2015 Aug;35(8):1415-21. (PMID: 25976307) Int J Mol Sci. 2024 Apr 04;25(7):. (PMID: 38612837) Br J Cancer. 2013 Oct 29;109(9):2496-501. (PMID: 24084773) Am J Med. 1995 Nov;99(5):480-4. (PMID: 7485204) J Immunol. 2009 Jan 1;182(1):274-82. (PMID: 19109158) Int J Rheum Dis. 2018 Jan;21(1):186-193. (PMID: 28544477) Intern Med. 2005 Apr;44(4):303-6. (PMID: 15897640) J Clin Endocrinol Metab. 2015 Jan;100(1):109-14. (PMID: 25272307) Mol Med. 2007 Sep-Oct;13(9-10):455-60. (PMID: 17932559) Mol Med Rep. 2021 Aug;24(2):. (PMID: 34184082) J Clin Endocrinol Metab. 2013 Jul;98(7):E1198-202. (PMID: 23780374) Front Immunol. 2022 Aug 11;13:953465. (PMID: 36032148) Am J Hum Genet. 2005 Apr;76(4):561-71. (PMID: 15719322) Lancet. 2016 Aug 27;388(10047):906-918. (PMID: 27038492) Eur Thyroid J. 2022 Jan 01;11(1):. (PMID: 34981746) Int Immunopharmacol. 2021 Nov;100:108089. (PMID: 34464884) Cell Death Differ. 2018 Mar;25(3):486-541. (PMID: 29362479) Expert Opin Ther Targets. 2014 Aug;18(8):945-60. (PMID: 24844303) J Autoimmun. 2015 Jun;60:32-9. (PMID: 25936594) Front Endocrinol (Lausanne). 2017 Jun 19;8:138. (PMID: 28674523) JCI Insight. 2016 Oct 20;1(17):e90045. (PMID: 27777982) Clin Pediatr Endocrinol. 2019;28(3):91-96. (PMID: 31384100) Ann N Y Acad Sci. 2008 Dec;1150:300-10. (PMID: 19120317) Semin Immunopathol. 2022 Jan;44(1):47-62. (PMID: 35088123) |
| فهرسة مساهمة: | Keywords: Mendelian randomization; autoimmune diseases; autoimmune thyroiditis; causality; genetic |
| تواريخ الأحداث: | Date Created: 20240924 Date Completed: 20240924 Latest Revision: 20240925 |
| رمز التحديث: | 20240925 |
| مُعرف محوري في PubMed: | PMC11416997 |
| DOI: | 10.3389/fendo.2024.1383221 |
| PMID: | 39314521 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2024.1383221 |