دورية أكاديمية
Methylglyoxal mediates the association between 2-hour plasma glucose and HbA1c with inflammation: The Maastricht Study.
| العنوان: | Methylglyoxal mediates the association between 2-hour plasma glucose and HbA1c with inflammation: The Maastricht Study. |
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| المؤلفون: | Sun D; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases., van Greevenbroek MMJ; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases., Scheijen JLJM; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases., Kelly J; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases., Schalkwijk CG; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases., Wouters K; Department of Internal Medicine, Maastricht University Medical Center.; CARIM School for Cardiovascular Diseases. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مستخلص: | Context: Glucose excursions in persons with diabetes may drive chronic inflammation. Methylglyoxal (MGO) is formed from glucose, is elevated in persons with diabetes, and is a potent glycating agent linked with inflammation. Objective: We investigated whether glucose excursions are associated with low-grade inflammation and whether MGO mediates this association. Design: We used data from The Maastricht Study, an extensive phenotyping study into the etiology of type 2 diabetes and its complications. Participants: Data of 3017 participants, who underwent an oral glucose tolerance test and where data on MGO levels and inflammation were available, were used. Main Outcome Measures: Linear regression analyses, adjusted for potential confounders, evaluated associations between fasting plasma glucose (FPG), 2-hours plasma glucose (2h-PG) and HbA1c and low-grade inflammation (stdβ, [95% confidence interval]), calculated from plasma concentrations of C-reactive protein, serum amyloid A, interleukin-6, interleukin-8, tumor necrosis factor and soluble intercellular adhesion molecule-1. Mediation analyses investigated whether MGO mediated these associations. Results: 2h-PG (0.172 [0.110; 0.234]) and HbA1c (0.148 [0.101; 0.196]), but not FPG (0.049 [-0.002; 0.100]), were associated with low-grade inflammation. 2h-PG and HbA1c were also associated with 2h-MGO (0.471 [0.407; 0.534], and 0.244 [0.195; 0.294], respectively). Furthermore, 2h-MGO was independently and positively associated with low-grade inflammation (0.078 [0.037, 0.120]). 2h-MGO mediated 23% of the association between 2h-PG and inflammation, and 16% of the association between HbA1c and inflammation. Conclusions: MGO mediates the association between post-load glucose excursions and HbA1c with inflammation, providing evidence for a role of postprandial MGO formation to hyperglycemia-induced low-grade inflammation. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.) |
| فهرسة مساهمة: | Keywords: Diabetes; cardiovascular complications; inflammation; methylglyoxal |
| تواريخ الأحداث: | Date Created: 20240924 Latest Revision: 20240924 |
| رمز التحديث: | 20240924 |
| DOI: | 10.1210/clinem/dgae640 |
| PMID: | 39315630 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgae640 |