التفاصيل البيبلوغرافية
| العنوان: |
Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells. |
| المؤلفون: |
Hao X; Department of Anesthesiology, The First Hospital of China Medical University, Shenyang 110001, China., Li Y; Department of Anesthesiology, The First Hospital of China Medical University, Shenyang 110001, China., Gao H; Department of Anesthesiology, The First Hospital of China Medical University, Shenyang 110001, China., Wang Z; Department of Pain Medicine, The First Hospital of China Medical University, Shenyang 110001, China., Fang B; Department of Anesthesiology, The First Hospital of China Medical University, Shenyang 110001, China. |
| المصدر: |
Biomolecules [Biomolecules] 2024 Sep 18; Vol. 14 (9). Date of Electronic Publication: 2024 Sep 18. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Basel, Switzerland : MDPI, 2011- |
| مواضيع طبية MeSH: |
Cell Differentiation*/drug effects , Anesthetics, Inhalation*/pharmacology , Neural Stem Cells*/drug effects , Neural Stem Cells*/metabolism , Neural Stem Cells*/cytology, Humans ; Animals ; Embryonic Stem Cells/drug effects ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Cell Self Renewal/drug effects |
| مستخلص: |
Inhalation anesthesia stands as a pivotal modality within clinical anesthesia practices. Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic effects, exerting bidirectional influences on the physiological state of the body and disease progression. These effects encompass impaired cognitive function, inhibition of embryonic development, influence on tumor progression, and so forth. For many years, inhaled anesthetics were viewed as inhibitors of stem cell fate regulation. However, there is now a growing appreciation that inhaled anesthetics promote stem cell biological functions and thus are now regarded as a double-edged sword affecting stem cell fate. In this review, the effects of inhaled anesthetics on self-renewal and differentiation of neural stem cells (NSCs), embryonic stem cells (ESCs), and cancer stem cells (CSCs) were summarized. The mechanisms of inhaled anesthetics involving cell cycle, metabolism, stemness, and niche of stem cells were also discussed. A comprehensive understanding of these effects will enhance our comprehension of how inhaled anesthetics impact the human body, thus promising breakthroughs in the development of novel strategies for innovative stem cell therapy approaches. |
| فهرسة مساهمة: |
Keywords: differentiation; inhaled anesthetics; proliferation; self-renewal; stem cells |
| المشرفين على المادة: |
0 (Anesthetics, Inhalation) |
| تواريخ الأحداث: |
Date Created: 20240928 Date Completed: 20240928 Latest Revision: 20240928 |
| رمز التحديث: |
20240929 |
| DOI: |
10.3390/biom14091167 |
| PMID: |
39334933 |
| قاعدة البيانات: |
MEDLINE |
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