دورية أكاديمية
Acute toxicity and preliminary therapeutic results of pelvic lymphadenectomy combined with transperineal interstitial implantation of 192IR and external beam radiotherapy for locally advanced prostate cancer.
| العنوان: | Acute toxicity and preliminary therapeutic results of pelvic lymphadenectomy combined with transperineal interstitial implantation of 192IR and external beam radiotherapy for locally advanced prostate cancer. |
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| المؤلفون: | Brindle JS, Benson RC Jr, Martinez A, Edmundson GK, Zincke H, Utz DC |
| المصدر: | Urology [Urology] 1985 Mar; Vol. 25 (3), pp. 233-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0366151 Publication Model: Print Cited Medium: Print ISSN: 0090-4295 (Print) Linking ISSN: 00904295 NLM ISO Abbreviation: Urology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Ridgewood, N.J., Professional Medical Services Co. |
| مواضيع طبية MeSH: | Brachytherapy*/adverse effects , Lymph Node Excision*, Adenocarcinoma/*radiotherapy , Iridium/*administration & dosage , Prostatic Neoplasms/*radiotherapy , Radioisotopes/*administration & dosage, Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/surgery ; Aged ; Combined Modality Therapy ; Humans ; Male ; Middle Aged ; Preoperative Care ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Tomography, X-Ray Computed |
| مستخلص: | We have developed a combined modality approach for treatment of locally advanced prostate cancer consisting of: surgical staging with lymphadenectomy; transperineal placement of afterloading needles for a course of 192Ir brachytherapy; and a course of moderate-dose external beam irradiation to tight prostatic fields. The flexibility of the treatment permits adaptation of the dose to any tumor configuration. A total of 23 patients have been treated to date; 18 are available for treatment review and 14 for acute toxicity analysis. Significant morbidity has occurred in only 2 patients, 1 with a pelvic hematoma and 1 with hematoma in the wound. Local tumor response has been excellent in all but 1 patient. A good degree of symptomatic improvement was observed at the three-month follow-up. This approach appears to be safe and effective at this time. A brief review of the technique and the rationale for its use are also presented. |
| المشرفين على المادة: | 0 (Radioisotopes) 44448S9773 (Iridium) |
| تواريخ الأحداث: | Date Created: 19850301 Date Completed: 19850402 Latest Revision: 20190713 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0090-4295(85)90318-8 |
| PMID: | 3976113 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0090-4295 |
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| DOI: | 10.1016/0090-4295(85)90318-8 |