دورية أكاديمية
Effect of clofibrate on branched-chain amino acid metabolism.
| العنوان: | Effect of clofibrate on branched-chain amino acid metabolism. |
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| المؤلفون: | Wagenmakers AJ, Veerkamp JH, Schepens JT, van Moerkerk HT |
| المصدر: | Biochemical pharmacology [Biochem Pharmacol] 1985 Jun 15; Vol. 34 (12), pp. 2169-73. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
| مواضيع طبية MeSH: | Amino Acids, Branched-Chain/*metabolism , Clofibrate/*pharmacology, 2-Oxoisovalerate Dehydrogenase (Acylating) ; Animals ; Decarboxylation ; In Vitro Techniques ; Ketone Oxidoreductases/analysis ; Liver/metabolism ; Male ; Muscles/metabolism ; Protein Binding ; Rats ; Rats, Inbred Strains ; Serum Albumin/metabolism |
| مستخلص: | Clofibric acid inhibited the oxidative decarboxylation of 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate in mitochondria and homogenates of rat liver and quadriceps muscle. In rat hemidiaphragms clofibric acid inhibited the oxidative decarboxylation of 4-methyl-2-oxopentanoate and had no effect on that of 3-methyl-2-oxobutanoate. Clofibric acid displaced branched-chain 2-oxo acids from bovine serum albumin. Clofibrate-treatment of rats decreased the actual activity and activity state of the branched-chain 2-oxo acid dehydrogenase complex in quadriceps muscle, and increased the total activity in heart and liver without a change of the activity state. All interactions of clofibric acid with the metabolism of branched-chain amino acids appear to relate to its structural resemblance to the branched-chain 2-oxo acids. Both reduced plasma and muscle concentrations of branched-chain amino acids and reduced muscle oxidation may play a role in the myopathic side-effects of clofibrate-treatment. |
| المشرفين على المادة: | 0 (Amino Acids, Branched-Chain) 0 (Serum Albumin) EC 1.2.- (Ketone Oxidoreductases) EC 1.2.1.25 (2-Oxoisovalerate Dehydrogenase (Acylating)) HPN91K7FU3 (Clofibrate) |
| تواريخ الأحداث: | Date Created: 19850615 Date Completed: 19850710 Latest Revision: 20190623 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0006-2952(85)90413-7 |
| PMID: | 4004935 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-2952 |
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| DOI: | 10.1016/0006-2952(85)90413-7 |