دورية أكاديمية
2-chain immunoglobulin A molecules: abnormal or normal intermediates in synthesis.
| العنوان: | 2-chain immunoglobulin A molecules: abnormal or normal intermediates in synthesis. |
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| المؤلفون: | Lieberman R, Mushinski JF, Potter M |
| المصدر: | Science (New York, N.Y.) [Science] 1968 Mar 22; Vol. 159 (3821), pp. 1355-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Neoplasm Proteins/*biosynthesis , Plasmacytoma/*immunology , Plasmacytoma/*metabolism , gamma-Globulins/*biosynthesis, Animals ; Chromatography ; Electrophoresis ; Mice ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/metabolism ; Peptides/analysis ; Precipitin Tests ; Trypsin |
| مستخلص: | Immunoglobulin A (gammaA) myeloma proteins secreted by plasma-cell tumors of mice are of two types, a common four-chain molecule and a rare two-chain (3.9S) molecule. The close similarity between two-chain gammaA molecules and four-chain gammaA molecules and their polymers is demonstrated in tryptic peptide maps of isolated polypeptide chains and by precipitin reactions with rabbit antiserums to gammaA immzunoglobulins. However, a difference between these two types is distinguishable with homologous antiserums. Homologous antiserums to two-chain gammaA immunoglobulins are specific and do not cross-react with four-chain gammaA immutnoglobulins. |
| المشرفين على المادة: | 0 (Neoplasm Proteins) 0 (Peptides) 0 (gamma-Globulins) EC 3.4.21.4 (Trypsin) |
| تواريخ الأحداث: | Date Created: 19680322 Date Completed: 19680523 Latest Revision: 20190618 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1126/science.159.3821.1355 |
| PMID: | 4171275 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0036-8075 |
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| DOI: | 10.1126/science.159.3821.1355 |