دورية أكاديمية
Mycobacterium ulcerans infection: treatment with rifampin, hyperbaric oxygenation, and heat.
| العنوان: | Mycobacterium ulcerans infection: treatment with rifampin, hyperbaric oxygenation, and heat. |
|---|---|
| المؤلفون: | Krieg RE, Wolcott JH, Meyers WM |
| المصدر: | Aviation, space, and environmental medicine [Aviat Space Environ Med] 1979 Sep; Vol. 50 (9), pp. 888-92. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Aerospace Medical Association Country of Publication: United States NLM ID: 7501714 Publication Model: Print Cited Medium: Print ISSN: 0095-6562 (Print) Linking ISSN: 00956562 NLM ISO Abbreviation: Aviat Space Environ Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005- > : Alexandria Va : Aerospace Medical Association Original Publication: Washington, Aerospace Medical Assn. |
| مواضيع طبية MeSH: | Hyperbaric Oxygenation*, Hot Temperature/*therapeutic use , Mycobacterium Infections/*therapy , Mycobacterium Infections, Nontuberculous/*therapy , Rifampin/*therapeutic use , Skin Ulcer/*therapy, Animals ; Mice ; Mycobacterium Infections, Nontuberculous/drug therapy ; Skin Ulcer/drug therapy ; Skin Ulcer/etiology |
| مستخلص: | The effectiveness of hyperbaric oxygenation (HBO), heat, and rifampin for treating mice infected with Mycobacterium ulcerans was analyzed. Four hundred mice were innouclated in the hind footpads with 10(8) organisms. The seven treatment groups (50 mice each) were HBO (2.5 ATA for 1.5 h, twice a day), rifampin (RIF) (20 mg/kg body weight/d), heat (mice maintained at 37 degrees C), and all combinations of the three treatments. The severity of infection in the treated mice was compared weekly for 20 weeks with that of infected controls. The most effective treatments were RIF/HEAT and RIF/HBO/HEAT, RIF/HBO/HEAT treatment was further evaluated to determine the effectiveness of treating mice at various stages of infection. Three hundred mice were inoculated in the hind footpads, and, as the infection progressed, they were separated into groups (50 mice/group) according to the severity of infection. The treatment groups were compared to positive controls. The effectiveness of therapy was indirectly proportional to the severity of infection. |
| فهرسة مساهمة: | Indexing Agency: NASA Local ID #: 80042100. |
| المشرفين على المادة: | VJT6J7R4TR (Rifampin) |
| تواريخ الأحداث: | Date Created: 19790901 Date Completed: 19791220 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 496758 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0095-6562 |
|---|