دورية أكاديمية
Facile preparation of 6-chloro-9-amino-2-hydroxyacridine, a urinary metabolite of quinacrine and quinacrine mustard.
| العنوان: | Facile preparation of 6-chloro-9-amino-2-hydroxyacridine, a urinary metabolite of quinacrine and quinacrine mustard. |
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| المؤلفون: | Tsou KC, Ledis S, Steiger E, Nietrzeba R |
| المصدر: | Journal of pharmaceutical sciences [J Pharm Sci] 1975 Aug; Vol. 64 (8), pp. 1418-9. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print ISSN: 0022-3549 (Print) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York, NY : Elsevier Original Publication: Easton, Pa., American Pharmaceutical Assn. |
| مواضيع طبية MeSH: | Quinacrine Mustard*/metabolism, Acridines/*metabolism , Quinacrine/*analogs & derivatives , Quinacrine/*metabolism, Acridines/chemical synthesis ; Animals ; Chromosomes/ultrastructure ; Rats ; Staining and Labeling |
| مستخلص: | 6-Chloro-9-amino-2-hydroxyacridine was found to be a metabolite of both quinacrine and the antimalarial alkylating agent quinacrine mustard. Its structure was confirmed by a one-step reaction of quinacrine with 48 percent hydrobromic acid. The presence of this compound as a metabolite of quinacrine mustard suggests a possible in vivo activation mechanism for its antitumor activity and a pharmacological basis for its toxicity to the liver. In vitro experiments showed that this new compound does react with chromosomes and, therefore, can be both a useful chromosome stain and an intercalating agent. |
| المشرفين على المادة: | 0 (Acridines) 4213-45-0 (Quinacrine Mustard) H0C805XYDE (Quinacrine) |
| تواريخ الأحداث: | Date Created: 19750801 Date Completed: 19751106 Latest Revision: 20190710 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/jps.2600640838 |
| PMID: | 50435 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-3549 |
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| DOI: | 10.1002/jps.2600640838 |