دورية أكاديمية
Competitive inhibition between folic acid and methotrexate for transport carrier in the rat small intestine.
| العنوان: | Competitive inhibition between folic acid and methotrexate for transport carrier in the rat small intestine. |
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| المؤلفون: | Chungi VS, Bourne DW, Dittert LW |
| المصدر: | Journal of pharmaceutical sciences [J Pharm Sci] 1979 Dec; Vol. 68 (12), pp. 1552-3. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print ISSN: 0022-3549 (Print) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York, NY : Elsevier Original Publication: Easton, Pa., American Pharmaceutical Assn. |
| مواضيع طبية MeSH: | Intestinal Absorption*, Folic Acid/*metabolism , Methotrexate/*metabolism, Animals ; Binding, Competitive ; Intestine, Small/metabolism ; Kinetics ; Male ; Rats |
| مستخلص: | Folic acid absorption from the lumen of the rat small intestine in situ obeyed Michaelis--Menten kinetics. The values of Vmax and Km for absorption were 4.63 x 10(-7) M/min and 1.21 x 10(-6) M, respectively. Folic acid and methotrexate were mutual competitive inhibitors of absorption. Their Ki values were 1.28 x 10(-6) and 1.9 x 10(-5) M, respectively. |
| المشرفين على المادة: | 935E97BOY8 (Folic Acid) YL5FZ2Y5U1 (Methotrexate) |
| تواريخ الأحداث: | Date Created: 19791201 Date Completed: 19800423 Latest Revision: 20190710 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jps.2600681225 |
| PMID: | 529052 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-3549 |
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| DOI: | 10.1002/jps.2600681225 |