دورية أكاديمية
Chloride transport in glands of frog skin.
| العنوان: | Chloride transport in glands of frog skin. |
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| المؤلفون: | Thompson IG, Mills JW |
| المصدر: | The American journal of physiology [Am J Physiol] 1983 Mar; Vol. 244 (3), pp. C221-6. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 0370511 Publication Model: Print Cited Medium: Print ISSN: 0002-9513 (Print) Linking ISSN: 00029513 NLM ISO Abbreviation: Am J Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Physiological Society Original Publication: Washington [etc.] American Physiological Society. |
| مواضيع طبية MeSH: | Skin Physiological Phenomena*, Chlorides/*metabolism , Sodium/*metabolism, 1-Methyl-3-isobutylxanthine/pharmacology ; Amiloride/pharmacology ; Animals ; Biological Transport, Active/drug effects ; Cyclic AMP/pharmacology ; Electric Conductivity ; Furosemide/pharmacology ; Isoproterenol/pharmacology ; Kinetics ; Rana catesbeiana ; Skin/drug effects |
| مستخلص: | The effects of beta-adrenergic stimulation on the bidirectional fluxes of Na+ and Cl- across the frog skin glands were determined. Isoproterenol elicited net serosal-to-mucosal fluxes of both Na+ (JNanet) and Cl- (JClnet) equal to 0.19 +/- 0.05 (SE) and 0.57 +/- 0.05 mueq X cm-2 X h-1, respectively. The residual current (JClnet - JNanet) of 0.38 +/- 0.05 mueq X cm-2 X h-1 closely approximates the isoproterenol-induced short-circuit current of 0.30 +/- 0.04 mueq X cm-2 X h-1. Furosemide added to the serosal side prior to isoproterenol inhibited the isoproterenol-induced net fluxes of both Na+ and Cl-. The addition of dibutyryl cAMP and 3-isobutyl-1-methylxanthine to the serosal side mimicked the action of isoproterenol by stimulating glandular short-circuit current. We conclude that an active Cl(-)-transport mechanism resides in the frog skin glands and is 1) stimulated by a beta-adrenergic agonist (its action is mimicked by cAMP) and 2) inhibited by the loop diuretic furosemide. |
| معلومات مُعتمدة: | HL-06664 United States HL NHLBI NIH HHS; R01-AM-32077 United States AM NIADDK NIH HHS |
| المشرفين على المادة: | 0 (Chlorides) 7DZO8EB0Z3 (Amiloride) 7LXU5N7ZO5 (Furosemide) 9NEZ333N27 (Sodium) E0399OZS9N (Cyclic AMP) L628TT009W (Isoproterenol) TBT296U68M (1-Methyl-3-isobutylxanthine) |
| تواريخ الأحداث: | Date Created: 19830301 Date Completed: 19830415 Latest Revision: 20171213 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1152/ajpcell.1983.244.3.C221 |
| PMID: | 6187217 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0002-9513 |
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| DOI: | 10.1152/ajpcell.1983.244.3.C221 |