دورية أكاديمية
Plasma ACTH and cortisol concentrations before and after dexamethasone.
| العنوان: | Plasma ACTH and cortisol concentrations before and after dexamethasone. |
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| المؤلفون: | Kalin NH, Weiler SJ, Shelton SE |
| المصدر: | Psychiatry research [Psychiatry Res] 1982 Aug; Vol. 7 (1), pp. 87-92. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print Cited Medium: Print ISSN: 0165-1781 (Print) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier/North-Holland Biomedical Press Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Dexamethasone*, Adrenocorticotropic Hormone/*blood , Depressive Disorder/*diagnosis , Hydrocortisone/*blood, Bipolar Disorder/blood ; Bipolar Disorder/diagnosis ; Depressive Disorder/blood ; Humans ; Male ; Radioimmunoassay |
| مستخلص: | Alteration in the hypothalamic-pituitary-adrenal (HPA) axis occurs in up to 50% of depressed patients and is demonstrated by the failure to suppress cortisol concentrations after dexamethasone administration. Evidence suggesting that these cortisol abnormalities reflect hypothalamic-pituitary dysfunction has been inconsistent. We administered the dexamethasone suppression test to 28 psychiatric inpatients, including 17 cortisol suppressors and 11 nonsuppressors. Adrenocorticotropic hormone (ACTH) concentrations at 8 a.m. pre- and postdexamethasone were significantly greater in cortisol nonsuppressors than in suppressors. Our data support the hypothesis that pituitary ACTH secretion is altered in depressed patients who have HPA axis abnormalities demonstrated by plasma cortisol measurements. |
| المشرفين على المادة: | 7S5I7G3JQL (Dexamethasone) 9002-60-2 (Adrenocorticotropic Hormone) WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 19820801 Date Completed: 19821218 Latest Revision: 20190825 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0165-1781(82)90056-7 |
| PMID: | 6291080 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0165-1781 |
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| DOI: | 10.1016/0165-1781(82)90056-7 |