دورية أكاديمية
Influence of lesions of the noradrenergic locus coeruleus system on the cerebral metabolic response to bicuculline-induced seizures.
| العنوان: | Influence of lesions of the noradrenergic locus coeruleus system on the cerebral metabolic response to bicuculline-induced seizures. |
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| المؤلفون: | Ingvar M, Lindvall O, Folbergrová J, Siesjö BK |
| المصدر: | Brain research [Brain Res] 1983 Apr 04; Vol. 264 (2), pp. 225-31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print Cited Medium: Print ISSN: 0006-8993 (Print) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Brain/*metabolism , Locus Coeruleus/*physiology , Norepinephrine/*physiology , Seizures/*metabolism, Animals ; Bicuculline ; Brain Chemistry ; Cyclic AMP/analysis ; Cyclic GMP/analysis ; Fatty Acids, Nonesterified/analysis ; Glycolysis ; Male ; Rats ; Rats, Inbred Strains ; Seizures/chemically induced |
| مستخلص: | The objective of the present study was to explore if lesions of the ascending noradrenergic pathways, originating in the locus coeruleus, modulate the cerebral metabolic response to bicuculline-induced seizures in rats. Bilateral noradrenergic lesions were performed by 6-hydroxydopamine injections in the caudal mesencephalon, 12-22 days before seizures were induced in animals ventilated on N2O:O2 (75:25). After 5 min of seizures the brain was frozen in situ and cerebral cortex and hippocampus were sampled for analysis. Labile phosphates, glycolytic metabolites, cyclic nucleotides, and free fatty acids were measured. In another series, lesioned animals were used for measurements of cerebral oxygen consumption. The noradrenergic lesions neither modified the electroencephalographically recorded seizure discharge, nor did they alter cerebral oxygen consumption or cerebral energy state. However, when compared to sham-operated animals, those with noradrenergic lesions had significantly higher (115% and 68%) glycogen concentrations and lower (50% and 52%) cyclic AMP concentrations in cerebral cortex and hippocampus, respectively, demonstrating the marked influence of noradrenergic activity on adenylate cyclase activity and glycogenolysis. The lesions failed to modulate the rise in free fatty acids in the cerebral cortex, or the cyclic GMP concentrations in the cerebral cortex and hippocampus. Thus, increased noradrenergic activity during status epilepticus does not seem responsible for lipolysis or for activation of guanylate cyclase. |
| معلومات مُعتمدة: | 2 RO1 NS-07838 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Fatty Acids, Nonesterified) E0399OZS9N (Cyclic AMP) H2D2X058MU (Cyclic GMP) X4W3ENH1CV (Norepinephrine) Y37615DVKC (Bicuculline) |
| تواريخ الأحداث: | Date Created: 19830404 Date Completed: 19830708 Latest Revision: 20190614 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0006-8993(83)90820-x |
| PMID: | 6303501 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-8993 |
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| DOI: | 10.1016/0006-8993(83)90820-x |