دورية أكاديمية
Syntheses and evaluation of some mannich bases derived from acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3-dimethyl-amino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride in rats.
| العنوان: | Syntheses and evaluation of some mannich bases derived from acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3-dimethyl-amino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride in rats. |
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| المؤلفون: | Dimmock JR, Shyam K, Logan BM, Smith PJ, Cross BM |
| المصدر: | Journal of pharmaceutical sciences [J Pharm Sci] 1984 Apr; Vol. 73 (4), pp. 471-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print ISSN: 0022-3549 (Print) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York, NY : Elsevier Original Publication: Easton, Pa., American Pharmaceutical Assn. |
| مواضيع طبية MeSH: | Acetophenones/*chemical synthesis , Antineoplastic Agents/*chemical synthesis , Leukemia P388/*drug therapy , Leukemia, Experimental/*drug therapy , Propiophenones/*chemical synthesis, Acetophenones/pharmacology ; Acetophenones/toxicity ; Animals ; Antineoplastic Agents/toxicity ; Body Weight/drug effects ; Male ; Mannich Bases/chemical synthesis ; Mice ; Propiophenones/pharmacology ; Propiophenones/toxicity ; Rats ; Rats, Inbred Strains |
| مستخلص: | A number of analogues of 3-dimethylamino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride (IIa) and related compounds which showed activity against P388 lymphocytic leukemia were prepared, and of the 16 analogues, three met the criterion for activity in this screen. The toxicity of IIa was examined in rats and either a single dose of 25 mg/kg or nine daily doses of 12.5 mg/kg administered by the intraperitoneal route produced marked irritation and damage to the tissue with which it came into contact. Compound IIa did not show significant activity against eight other tumor systems. |
| المشرفين على المادة: | 0 (Acetophenones) 0 (Antineoplastic Agents) 0 (Mannich Bases) 0 (Propiophenones) 90548-62-2 (3-dimethylamino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone) |
| تواريخ الأحداث: | Date Created: 19840401 Date Completed: 19840709 Latest Revision: 20190711 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/jps.2600730411 |
| PMID: | 6547174 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-3549 |
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| DOI: | 10.1002/jps.2600730411 |