دورية أكاديمية
أعرض في EDS

Chromosome analysis from peripheral blood lymphocytes of workers after an acute exposure to benzene.

التفاصيل البيبلوغرافية
العنوان: Chromosome analysis from peripheral blood lymphocytes of workers after an acute exposure to benzene.
المؤلفون: Clare MG, Yardley-Jones A, Maclean AC, Dean BJ
المصدر: British journal of industrial medicine [Br J Ind Med] 1984 May; Vol. 41 (2), pp. 249-53.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: British Medical Assn Country of Publication: England NLM ID: 0370637 Publication Model: Print Cited Medium: Print ISSN: 0007-1072 (Print) Linking ISSN: 00071072 NLM ISO Abbreviation: Br J Ind Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : British Medical Assn.
مواضيع طبية MeSH: Accidents, Occupational* , Chromosome Aberrations* , Occupational Medicine*, Benzene/*poisoning , Crossing Over, Genetic/*drug effects , Lymphocytes/*ultrastructure , Sister Chromatid Exchange/*drug effects, Environmental Exposure ; Humans ; Lymphocytes/drug effects ; Male ; Phenol ; Phenols/urine ; Time Factors
مستخلص: A spillage of about 1200 gallons of benzene occurred during the loading of a ship, and 10 workers on a single shift were exposed to benzene. Shortly afterwards, an assay of the urine of these individuals showed that substantial amounts of phenol were being excreted. About three months after the incident samples of venous blood were taken from 10 individuals exposed to benzene and 11 men on a comparable shift who acted as controls. The lymphocytes were stimulated to divide in short term cultures. For each subject, 200 cells at metaphase were examined for chromosome damage using 48 h cultures, and sister chromatid exchanges (SCE) were analysed from about 30 cells in their second division, using 72 h cultures. The most frequent types of aberrations in all the individuals were chromatid gaps, with occasional breaks of chromatids and chromosomes. There were few exchanges within or between the arms of chromatids or chromosomes. More cells in the control than in the exposed group showed damage, an effect that was especially noticeable for chromatid gaps. All values, however, were considered to be within a normal range. There were slightly more SCE in some of the exposed individuals than in the controls and there was a trend towards a positive association between the frequency of SCE recorded for each individual and the maximum value for the excretion of phenol in the urine on the day after the incident. There is no evidence to indicate that benzene induced any type of lasting chromosome damage in the lymphocytes of the 10 exposed workers when cells were examined about three months after the incident.
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المشرفين على المادة: 0 (Phenols)
339NCG44TV (Phenol)
J64922108F (Benzene)
تواريخ الأحداث: Date Created: 19840501 Date Completed: 19840622 Latest Revision: 20190503
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1009291
DOI: 10.1136/oem.41.2.249
PMID: 6722051
قاعدة البيانات: MEDLINE
الوصف
تدمد:0007-1072
DOI:10.1136/oem.41.2.249