دورية أكاديمية
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
| العنوان: | Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis. |
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| المؤلفون: | Feo F, Canuto RA, Garcea R, Brossa O, Caselli GC |
| المصدر: | Cancer letters [Cancer Lett] 1978 Jul; Vol. 5 (1), pp. 25-30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print Cited Medium: Print ISSN: 0304-3835 (Print) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Ethionine*, Aminopyrine N-Demethylase/*metabolism , Cytochrome P-450 Enzyme System/*metabolism , Liver Neoplasms, Experimental/*metabolism , Phenobarbital/*pharmacology , Precancerous Conditions/*metabolism, Animals ; Hyperplasia/metabolism ; Liver Neoplasms, Experimental/chemically induced ; Male ; Microsomes, Liver/metabolism ; Neoplasm Proteins/metabolism ; Precancerous Conditions/chemically induced ; Rats |
| مستخلص: | Microsomes isolated from hyperplastic liver nodules and hepatomas, induced by DL-ethionine, exhibited a reduced cytochrome P-450 content and aminopyrine N-demethylase activity when compared to the organelles of control and surrounding non-nodular liver. Phenobarbital administration to rats caused an increase of microsomal protein, cytochrome P-450 and aminopyrine N-demethylase in all tissue tested. In the hepatoma the rise of cytochrome P-450 and aminopyrine N-demethylase/g of tissue was very low and it is compensated by a slight increase of microsomal protein. In hyperplastic nodules as well as in control and surrounding livers, cytochrome P-450 and aminopyrine N-demethylase increased more than microsomal protein. However, the phenobarbital-induced stimulation was significantly lower in hyperplastic nodules than in control and surrounding livers. |
| المشرفين على المادة: | 0 (Neoplasm Proteins) 9035-51-2 (Cytochrome P-450 Enzyme System) EC 1.5.3.- (Aminopyrine N-Demethylase) WX1BN24WZT (Ethionine) YQE403BP4D (Phenobarbital) |
| تواريخ الأحداث: | Date Created: 19780701 Date Completed: 19781118 Latest Revision: 20190720 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/s0304-3835(78)80006-8 |
| PMID: | 688180 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0304-3835 |
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| DOI: | 10.1016/s0304-3835(78)80006-8 |