دورية أكاديمية
Reduced T lymphoid colony growth in patients with progressive systemic sclerosis and rheumatoid arthritis.
| العنوان: | Reduced T lymphoid colony growth in patients with progressive systemic sclerosis and rheumatoid arthritis. |
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| المؤلفون: | Winkelstein A, Bernstein ML, Stevens MA, Rodnan GP, Medsger TA Jr, Dobson SA |
| المصدر: | The Journal of laboratory and clinical medicine [J Lab Clin Med] 1982 Aug; Vol. 100 (2), pp. 240-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0375375 Publication Model: Print Cited Medium: Print ISSN: 0022-2143 (Print) Linking ISSN: 00222143 NLM ISO Abbreviation: J Lab Clin Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: -2006: New York, NY : Elsevier Original Publication: St. Louis, C.V. Mosby, -[2006]. |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid/*blood , Scleroderma, Systemic/*blood , T-Lymphocytes/*cytology, Adult ; Aged ; Colony-Forming Units Assay ; Female ; Humans ; In Vitro Techniques ; Lupus Erythematosus, Systemic/blood ; Male ; Middle Aged ; Phytohemagglutinins/pharmacology |
| مستخلص: | T cell colony growth in semisolid medium, a sensitive indicator of disease-associated lymphoycte defects, was found to be depressed in patients with PSS and RA. In both disorders, more pronounced abnormalities were observed after incubation with suboptimal concentrations of the polyclonal mitogen PHA. Depletion of monocytes by adherence to plastic surfaces of addition of the prostaglandin synthetase inhibitor indomethacin did not correct the growth abnormality observed in PSS. Reduced colony-forming activity could not be attributed to serum inhibitory factors. The cellular abnormalities detected in patients with these connective tissue diseases were less pronounced than those found in SLE patients. |
| معلومات مُعتمدة: | CA 24429 United States CA NCI NIH HHS; FR-00056 United States PHS HHS |
| المشرفين على المادة: | 0 (Phytohemagglutinins) |
| تواريخ الأحداث: | Date Created: 19820801 Date Completed: 19820910 Latest Revision: 20141120 |
| رمز التحديث: | 20221213 |
| PMID: | 6980249 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-2143 |
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