دورية أكاديمية
A study of posterior column function in familial spastic paraplegia.
| العنوان: | A study of posterior column function in familial spastic paraplegia. |
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| المؤلفون: | Dimitrijevic MR, Lenman JA, Prevec T, Wheatly K |
| المصدر: | Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 1982 Jan; Vol. 45 (1), pp. 46-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print Cited Medium: Print ISSN: 0022-3050 (Print) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BMJ Publishing Group Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Paraplegia/*genetics , Spinal Cord/*physiopathology, Adolescent ; Adult ; Aged ; Child ; Evoked Potentials, Somatosensory ; Genes, Dominant ; Humans ; Middle Aged ; Motor Neurons ; Muscle Spasticity/genetics ; Neural Conduction ; Paraplegia/physiopathology ; Syndrome |
| مستخلص: | A family is described in which affected members have clinical features consistent with the late onset form of Strümpell's Familial Spastic Paraplegia which is of dominant inheritance. Abnormalities in cortical somatosensory to peroneal nerve stimulation were found in all affected members of the family and in several who were clinically unaffected. In some cases responses were better defined at slow rates of stimulation. Peripheral nerve conduction velocity was normal. These changes are consistent with previous findings of degeneration in the posterior columns at necroscopy and with a dying back process in the first sensory neuron. Clinically unaffected members of the family with abnormalities in the somatosensory response may represent asymptomatic heterozygotes. |
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| تواريخ الأحداث: | Date Created: 19820101 Date Completed: 19820527 Latest Revision: 20190501 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC491263 |
| DOI: | 10.1136/jnnp.45.1.46 |
| PMID: | 7062069 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-3050 |
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| DOI: | 10.1136/jnnp.45.1.46 |