دورية أكاديمية
Effect of a new 5 alpha-reductase inhibitor on size, histologic characteristics, and androgen concentrations of the canine prostate.
| العنوان: | Effect of a new 5 alpha-reductase inhibitor on size, histologic characteristics, and androgen concentrations of the canine prostate. |
|---|---|
| المؤلفون: | Brooks JR, Berman D, Glitzer MS, Gordon LR, Primka RL, Reynolds GF, Rasmusson GH |
| المصدر: | The Prostate [Prostate] 1982; Vol. 3 (1), pp. 35-44. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8101368 Publication Model: Print Cited Medium: Print ISSN: 0270-4137 (Print) Linking ISSN: 02704137 NLM ISO Abbreviation: Prostate Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : Wiley-Liss Original Publication: New York : Alan R. Liss, c1980- |
| مواضيع طبية MeSH: | 5-alpha Reductase Inhibitors*, Azasteroids/*pharmacology , Dihydrotestosterone/*analogs & derivatives , Dihydrotestosterone/*analysis , Oxidoreductases/*antagonists & inhibitors , Prostate/*drug effects , Steroids, Heterocyclic/*pharmacology , Testosterone/*analysis, Animals ; Atrophy/chemically induced ; Dihydrotestosterone/pharmacology ; Dogs ; Dose-Response Relationship, Drug ; Male ; Organ Size/drug effects ; Prostate/pathology ; Spermatogenesis/drug effects |
| مستخلص: | Mature male beagles were used in studies designed to determine the effect of the steroidal 5 alpha-reductase inhibitor 17 beta-N,N-diethylcarbamoyl-4-aza-4-methyl-5 alpha-androstan-3-one (4-MA) on size, histology, and androgen concentration of the prostate. Subcutaneous administration of 3 or 15 mg/kg/day for 43 days caused a sharp decline in prostate volume. flattening of prostatic epithelial cells, vacuolization of the cytoplasm and pycnosis of the nuclei. Whereas serum testosterone levels remained normal in dogs injected with 3 mg/kg/day, they were lower in those that received 15 mg/kg/day. Concentration of both testosterone and 5 alpha-dihydrotestosterone were reduced in the prostates of dogs that had received either 3 or 15 mg/kg/day of 4-MA. The 15 mg/kg/day level also appeared to adversely affect spermatogenesis. In a 43-day study, 4-MA given orally once each day at levels of 0.1, 0.3, or 1 mg/kg failed to cause a significant decrease in prostate volume. However, daily divided oral doses totaling 1 or 3 mg/kg were given in a 42-day test and both treatment levels produced significant reductions in prostate size. |
| المشرفين على المادة: | 0 (5-alpha Reductase Inhibitors) 0 (Azasteroids) 0 (Steroids, Heterocyclic) 08J2K08A3Y (Dihydrotestosterone) 3XMK78S47O (Testosterone) 73671-86-0 (17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one) EC 1.- (Oxidoreductases) |
| تواريخ الأحداث: | Date Created: 19820101 Date Completed: 19820708 Latest Revision: 20190913 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/pros.2990030107 |
| PMID: | 7079196 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0270-4137 |
|---|---|
| DOI: | 10.1002/pros.2990030107 |