دورية أكاديمية
[Hypocholesterolemic effect of phytoecdysones during experimental hypercholesterolemia in rats].
| العنوان: | [Hypocholesterolemic effect of phytoecdysones during experimental hypercholesterolemia in rats]. |
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| عنوان ترانسليتريتد: | Gipokholesterinemicheskoe deĭstvie fitoékzidonov pri éksperimental'noĭ giperkholesterinemii u krys. |
| المؤلفون: | Mironova VN, Kholodova IuD, Skachkova TF, Bondar' OP, Datsenko ZM |
| المصدر: | Voprosy meditsinskoi khimii [Vopr Med Khim] 1982 May-Jun; Vol. 28 (3), pp. 101-5. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiĭskai︠a︡ Akademii︠a︡ Medit︠s︡inskikh Nauk Country of Publication: Russia (Federation) NLM ID: 0416601 Publication Model: Print Cited Medium: Print ISSN: 0042-8809 (Print) Linking ISSN: 00428809 NLM ISO Abbreviation: Vopr Med Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Rossiĭskai︠a︡ Akademii︠a︡ Medit︠s︡inskikh Nauk Original Publication: Moskva. |
| مواضيع طبية MeSH: | Cholesterol/*metabolism , Ecdysone/*therapeutic use , Hypercholesterolemia/*drug therapy , Phytosterols/*therapeutic use, Animals ; Cholesterol, Dietary ; Hypercholesterolemia/etiology ; Hypercholesterolemia/metabolism ; Intestinal Absorption/drug effects ; Phospholipids/metabolism ; Rats |
| مستخلص: | The most active hypocholesterolemic preparation, affecting the absorption of 3H1-cholesterol in small intestine of rats with experimental hypercholesterolemia, proved to be I-hydroxyecdisterone; the activity was gradually decreased in the following series of preparations: ecdisterone, steroid sapogenine allyogenone, ciasterone and ecdisterone 25 acetate. Thus, the hypocholesterolemic activity of the preparations was increased with an increase in the content of hydroxy groups in the molecules. After daily administration of ecdisterone at a dose of 2.5 mg/kg into the animals with hypercholesterolemia within 3, 6 and 8 weeks, content of cholesterol in blood plasma was decreased by 7.0%, 16.9% and 29%, respectively; this phenomenon was accompanied by a decrease of the cholesterol content in erythrocyte membranes as well as in microfilaments of erythrocyte border by 26% and 34%, respectively. Amount of phospholipids and the ratio cholesterol/phospholipids were also normalized in the membranes studied. The data obtained suggest that competitive relationship occurs between cholesterol and the hypocholesterolemic drugs during binding with the membrane sites depending on their concentrations in blood plasma, intestine lumen and on the content in the membranes. |
| المشرفين على المادة: | 0 (Cholesterol, Dietary) 0 (Phospholipids) 0 (Phytosterols) 0 (phytoecdysones) 3604-87-3 (Ecdysone) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 19820501 Date Completed: 19820924 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 7101810 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-8809 |
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