دورية أكاديمية
Reduced dopaminergic inhibition of thyrotrophin release in states of physiological hyperprolactinaemia.
| العنوان: | Reduced dopaminergic inhibition of thyrotrophin release in states of physiological hyperprolactinaemia. |
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| المؤلفون: | Rodriguez-Arnao MD, Weightman DR, Hall R, Scanlon MF, Camporro JM, Gomez-Pan A |
| المصدر: | Clinical endocrinology [Clin Endocrinol (Oxf)] 1982 Jul 01; Vol. 17 (1), pp. 15-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print Cited Medium: Print ISSN: 0300-0664 (Print) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Oxford : Blackwell Publishing Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Postpartum Period*, Metoclopramide/*pharmacology , Prolactin/*blood , Thyroid Gland/*drug effects , Thyrotropin/*metabolism, Adult ; Female ; Humans ; Hypothalamus/drug effects ; Pregnancy ; Thyroid Gland/metabolism |
| مستخلص: | We have tested the hypothesis that physiological puerperal hyperprolactinaemia may be secondary to reduced hypothalamic dopaminergic inhibition of prolactin (PRL) release. Nine post-partum females with physiological hyperprolactinaemia (aged 19-40 years; mean basal PRL +/- SE, 2099 +/- 257 mU/1, range 1002-3762 mU/1) were studied and results compared with fourteen normoprolactinaemic females (basal PRL less than 400 mU/1; aged 18-36 years). Puerperal hyperprolactinaemic females showed a reduced TSH response to dopamine (DA) receptor blockade with metoclopramide (10 mg i.v.) compared with normal females over a 60-min period following drug administration (total incremental TSH change, mean +/- SE, mU/1; 0.5 +/- 0.3 v. 3.1 +/- 1.0 P less than 0.005). This finding of reduced dopaminergic inhibition of TSH release in females with physiological puerperal hyperprolactinaemia supports the view that an overall reduction in hypothalamic dopaminergic tone may contribute towards hyperprolactinaemia in post-partum women. |
| المشرفين على المادة: | 9002-62-4 (Prolactin) 9002-71-5 (Thyrotropin) L4YEB44I46 (Metoclopramide) |
| تواريخ الأحداث: | Date Created: 19820701 Date Completed: 19821202 Latest Revision: 20190813 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/j.1365-2265.1982.tb02629.x |
| PMID: | 7116653 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0300-0664 |
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| DOI: | 10.1111/j.1365-2265.1982.tb02629.x |