دورية أكاديمية
Anaesthetic induction for Caesarean section with propanidid.
| العنوان: | Anaesthetic induction for Caesarean section with propanidid. |
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| المؤلفون: | Mahomedy MC, Downing JW, Jeal DE, Coleman AJ |
| المصدر: | Anaesthesia [Anaesthesia] 1976 Mar; Vol. 31 (2), pp. 205-11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0370524 Publication Model: Print Cited Medium: Print ISSN: 0003-2409 (Print) Linking ISSN: 00032409 NLM ISO Abbreviation: Anaesthesia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Wiley-Blackwell Original Publication: London, Academic Press; New York, Grune & Stratton. |
| مواضيع طبية MeSH: | Cesarean Section* , Propanidid*/administration & dosage , Propanidid*/adverse effects, Anesthesia, Intravenous/*methods , Anesthesia, Obstetrical/*methods, Anesthesia, Intravenous/adverse effects ; Carbon Dioxide/blood ; Female ; Fetal Blood/analysis ; Fetus/drug effects ; Humans ; Hydrogen-Ion Concentration ; Maternal-Fetal Exchange ; Mental Recall/drug effects ; Oxygen/blood ; Pregnancy ; Thiopental/administration & dosage |
| مستخلص: | Propanidid was used for the induction of anaesthesia at Caesarean section in 50 healthy mothers. All parturients were considered to have normal placental function. Anaesthesia was maintained with nitrous oxide, oxygen, muscle relaxant and controlled ventilation. The patients were tilted laterally with a 15 degrees rubber wedge during the procedure in order to obviate the effects of aorta-caval occlusion. At the time of delivery, arterial blood was drawn from the mother and from the vessels of a double clamped section of umbilical cord, for blood-gas analysis. The results obtained are compared with those previously reported in a similar series anaesthetised with thiopentone, gas, oxygen and relaxant. Maternal blood-gas and acid-base levels were similar in the two groups at delivery. The clinical status of the infants in the present series, as judged by the modified Apgar score at 2 minutes after birth, was satisfactory. Umbilical venous and arterial pH values after propanidid were both 0-054 units (P less than 0-001) less than those following thiopentone; and average base deficits were 3-1 (Uv) and 3-9 (Ua) mEq/litre greater after propanidid (P less than 0-001). Mean oxygen levels in the umbilical cord bloods were 8-0 (Uv) and 3-5 (Ua) mmHg lower (P less than 0-001 & P less than 0-025 respectively) in the propanidid group. Derived oxygen contents was also significantly less than in the previous thiopentone series. (Ma-Uv) and (Ma-Ua) gradients were 0-053 and 0-051 pH units higher after propanidid than that following thiopentone (P less than 0-001). Mean (Ma-Uv) and (Ma-Ua) base deficits were 3-5 and 3-9 mEq/litre greater (P less than 0-001). Five patients offered definite evidence of factual recall, of whom three experienced pain. Propanidid, therefore, appeared to be associated with a greater degree of foetal acidaemia than did thiopentone. In addition, painful factual recall during surgery was encountered in 6 percent of cases. It is concluded that propanidid, although theoretically offering advantages over thiopentone to the obstetric anaesthetist, in practice, did not fulfil this promise. |
| المشرفين على المادة: | 142M471B3J (Carbon Dioxide) AO82L471NS (Propanidid) JI8Z5M7NA3 (Thiopental) S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 19760301 Date Completed: 19760823 Latest Revision: 20190703 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1365-2044.1976.tb11792.x |
| PMID: | 7151 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0003-2409 |
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| DOI: | 10.1111/j.1365-2044.1976.tb11792.x |