دورية أكاديمية
Antiviral activity and mechanism of action of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860).
| العنوان: | Antiviral activity and mechanism of action of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860). |
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| المؤلفون: | Torney HL, Dulworth JK, Steward DL |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1982 Oct; Vol. 22 (4), pp. 635-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | Antiviral Agents/*pharmacology , Nitriles/*pharmacology, Animals ; Cells, Cultured ; Chlorocebus aethiops ; Cytopathogenic Effect, Viral/drug effects ; HeLa Cells ; Picornaviridae/metabolism ; RNA, Viral/biosynthesis ; Viral Plaque Assay |
| مستخلص: | A nitrobenzene derivative, MDL-860, was found to inhibit plaque formation, cytopathic effect, or both in 11 of 12 picornaviruses at concentrations which did not affect cell growth. The compound did not directly inactivate the virus. MDL-860 inhibited actinomycin D-resistant [3H]uridine uptake in cells infected with coxsackievirus A21 or rhinovirus 1-A, whereas incorporation into uninfected cells was not inhibited. With three picornaviruses (echovirus type 12, poliovirus type 2, and rhinovirus type 1-A) made photosensitive with neutral red, MDL-860 did not appear to cause a significant reduction in their loss of photosensitivity (uncoating) during the first 3 h of infection. MDL-860 appears to inhibit some early event in virus replication, after uncoating, which is required for synthesis of a majority of viral RNA. |
| References: | Virology. 1967 Apr;31(4):702-12. (PMID: 4164534) Proc Soc Exp Biol Med. 1969 Jun;131(2):588-92. (PMID: 4306808) Virology. 1979 Sep;97(2):307-15. (PMID: 224584) Antimicrob Agents Chemother. 1981 Oct;20(4):518-24. (PMID: 6282196) Antimicrob Agents Chemother. 1982 Oct;22(4):639-42. (PMID: 7181475) |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Nitriles) 0 (RNA, Viral) 78940-62-2 (2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile) |
| تواريخ الأحداث: | Date Created: 19821001 Date Completed: 19830214 Latest Revision: 20210526 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC183805 |
| DOI: | 10.1128/AAC.22.4.635 |
| PMID: | 7181474 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0066-4804 |
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| DOI: | 10.1128/AAC.22.4.635 |