دورية أكاديمية
Synthesis and antimetastatic properties of steroeoisomeric trycylic bis(dioxopiperazine) analogues in a B16 melanoma model.
| العنوان: | Synthesis and antimetastatic properties of steroeoisomeric trycylic bis(dioxopiperazine) analogues in a B16 melanoma model. |
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| المؤلفون: | Witiak DT, Trivedi BK, Campolito LB, Zwilling BS, Reiches NA |
| المصدر: | Journal of medicinal chemistry [J Med Chem] 1981 Nov; Vol. 24 (11), pp. 1329-32. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
| مواضيع طبية MeSH: | Antineoplastic Agents/*chemical synthesis , Melanoma/*drug therapy , Piperazines/*chemical synthesis, Animals ; Chemical Phenomena ; Chemistry ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/prevention & control ; Neoplasms, Experimental/drug therapy ; Piperazines/pharmacology ; Stereoisomerism |
| مستخلص: | The synthesis for trans and cis tricyclic bis(dioxopiperazine)s 5 and 6 from pyrazine-2,3-dicarboxamide (7) is described. Stereoselective antimetastatic activity differences for these analogues were observed following pretreatment of B16-F10 melanoma cells in vitro. Activities for these isomers were compared with selected intermediates, and the data are discussed in relation to previous results obtained with cis- and trans-cyclopropane analogues. |
| معلومات مُعتمدة: | CA 25445 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Piperazines) |
| تواريخ الأحداث: | Date Created: 19811101 Date Completed: 19820212 Latest Revision: 20190709 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1021/jm00143a013 |
| PMID: | 7310809 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0022-2623 |
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| DOI: | 10.1021/jm00143a013 |