دورية أكاديمية
Cutaneous manifestations in rats with advanced vitamin A deficiency.
| العنوان: | Cutaneous manifestations in rats with advanced vitamin A deficiency. |
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| المؤلفون: | Klein-Szanto AJ, Martin DH, Pine AH |
| المصدر: | Journal of cutaneous pathology [J Cutan Pathol] 1980 Aug; Vol. 7 (4), pp. 260-70. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 0425124 Publication Model: Print Cited Medium: Print ISSN: 0303-6987 (Print) Linking ISSN: 03036987 NLM ISO Abbreviation: J Cutan Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malden, MA : Wiley Original Publication: Copenhagen, Blackwell Munksgaard. |
| مواضيع طبية MeSH: | Skin/*pathology , Skin Diseases/*etiology , Vitamin A Deficiency/*complications, Animals ; Animals, Newborn ; Female ; Male ; Pregnancy ; Rats ; Skin/ultrastructure ; Skin Diseases/pathology ; Vitamin A Deficiency/pathology |
| مستخلص: | Specific-pathogen-free rats kept on a vitamin A-deficient diet for approximately 5 months developed cutaneous alterations, especially in the periorbital and eyelid skin. These lesions were characterized grossly by erythema, partial alopecia, and crusting, and histologically by hyperorthokeratinization, acanthosis, and a three-fold increase in incorporation of labeled DNA precursors into the epidermal basal layer. Electron microscopy showed an increased number of Langerhans cells with and without Birbeck granules, as well as the presence of cytoplasmic dense bodies of probable lipid nature in keratinocytes of all epidermal strata. The similarities of these ultrastructural alterations with some features of vitamin A-sensitive human dermatoses point to probable common mechanisms in the pathogenesis of these skin diseases. |
| معلومات مُعتمدة: | Y01 CP 90207 United States CP NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 19800801 Date Completed: 19810129 Latest Revision: 20190909 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1111/j.1600-0560.1980.tb01224.x |
| PMID: | 7430481 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0303-6987 |
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| DOI: | 10.1111/j.1600-0560.1980.tb01224.x |