دورية أكاديمية
Epstein-Barr virus activity in patients on chronic hemodialysis.
| العنوان: | Epstein-Barr virus activity in patients on chronic hemodialysis. |
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| المؤلفون: | Yamamoto T; Department of Clinical Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan., Nakajima Y, Yamamoto M, Hironaka T, Hirai K, Nakamura Y |
| المصدر: | Nephron [Nephron] 1995; Vol. 70 (4), pp. 449-54. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0331777 Publication Model: Print Cited Medium: Print ISSN: 1660-8151 (Print) Linking ISSN: 16608151 NLM ISO Abbreviation: Nephron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger |
| مواضيع طبية MeSH: | Immunocompromised Host*, Cytomegalovirus Infections/*etiology , Herpesviridae Infections/*etiology , Kidney Failure, Chronic/*virology , Renal Dialysis/*adverse effects , Tumor Virus Infections/*etiology, Adult ; Antibodies, Viral/blood ; Antigens, Viral/blood ; DNA, Viral/blood ; DNA-Binding Proteins/blood ; Epstein-Barr Virus Nuclear Antigens ; Female ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunoblotting ; Kidney Failure, Chronic/immunology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; RNA-Binding Proteins/blood |
| مستخلص: | Patients with uremia are susceptible to viral infections, especially to Epstein-Barr virus (EBV). Sixty-one patients with end-stage renal diseases on chronic hemodialysis (HD), 14 patients with impaired renal function (CRF), and 27 healthy controls were studied with regard to EBV infection. Uremic patients (HD and CRF) had a significantly higher incidence of EBV infection and higher titers of anti-EBV VCA-IgG antibody than healthy controls. The anti-EBNA-1 titer was significantly higher in patients whose dialysis period was more than 3 months than in whom the dialysis period was 3 months or less. Immunoblotting analysis also showed stronger EBNA-1 signals in hemodialysis patients than EBNA-2, which was strongly detected in the CRF group and in healthy controls. EBV DNA was detected by Southern blot hybridization after PCR amplification of peripheral leukocytes, and occurred at a greater incidence in hemodialysis patients than in the other groups. Taken together, these results demonstrated that hemodialysis patients had persistent EBV infection. |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antigens, Viral) 0 (DNA, Viral) 0 (DNA-Binding Proteins) 0 (Epstein-Barr Virus Nuclear Antigens) 0 (RNA-Binding Proteins) |
| تواريخ الأحداث: | Date Created: 19950101 Date Completed: 19951124 Latest Revision: 20180215 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000188644 |
| PMID: | 7477651 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1660-8151 |
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| DOI: | 10.1159/000188644 |