دورية أكاديمية
Modulation of renin-angiotensin and kallikrein gene expression in experimental hypertension.
| العنوان: | Modulation of renin-angiotensin and kallikrein gene expression in experimental hypertension. |
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| المؤلفون: | Von Thun AM; Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112., el-Dahr SS, Vari RC, Navar LG |
| المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 1994 Jan; Vol. 23 (1 Suppl), pp. I131-6. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Print ISSN: 0194-911X (Print) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| مواضيع طبية MeSH: | Gene Expression Regulation* , Renin-Angiotensin System*, Angiotensin II/*biosynthesis , Angiotensinogen/*biosynthesis , Hypertension, Renovascular/*metabolism , Kallikreins/*biosynthesis , Kidney/*enzymology , Renin/*biosynthesis, Angiotensin II/blood ; Animals ; Blood Pressure ; Blotting, Northern ; Hypertension, Renovascular/physiopathology ; Male ; RNA/isolation & purification ; RNA/metabolism ; RNA, Messenger/analysis ; RNA, Messenger/biosynthesis ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Renin/blood |
| مستخلص: | Previous studies have shown that chronic low-dose administration of 40 ng/min angiotensin II by osmotic minipump to uninephrectomized rats mimics the temporal hypertensive response and the circulating angiotensin II levels observed in two-kidney, one clip Goldblatt rats. Furthermore, renal tissue angiotensin II contents were higher than the circulating angiotensin II levels, suggesting that circulating angiotensin II induces endogenous intrarenal angiotensin II production. The present study examined the molecular mechanisms by which intrarenal angiotensin II production is modulated in angiotensin II-induced and two-kidney Goldblatt hypertension. Two weeks after clipping, intrarenal renin mRNA levels were elevated threefold in the clipped kidney of Goldblatt rats but were markedly suppressed in the nonclipped kidneys of Goldblatt rats (28% of control values) and in the remaining kidney of uninephrectomized angiotensin II-infused rats (7% of control values). In contrast, there were sustained levels of angiotensinogen mRNA in the kidneys and livers of Goldblatt and angiotensin II-infused rats, indicating differential regulation of the genes of the renin-angiotensin system. Renal kallikrein gene expression was not altered in either of the hypertensive groups 14 days after the induction of hypertension, suggesting the absence of an enhanced counteracting kinin influence. |
| معلومات مُعتمدة: | HL-26371 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (RNA, Messenger) 11002-13-4 (Angiotensinogen) 11128-99-7 (Angiotensin II) 63231-63-0 (RNA) EC 3.4.21.- (Kallikreins) EC 3.4.23.15 (Renin) |
| تواريخ الأحداث: | Date Created: 19940101 Date Completed: 19940216 Latest Revision: 20190722 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1161/01.hyp.23.1_suppl.i131 |
| PMID: | 7506697 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0194-911X |
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| DOI: | 10.1161/01.hyp.23.1_suppl.i131 |