التفاصيل البيبلوغرافية
| العنوان: |
Streptokinase gene variable region classification in streptococci: lack of correlation with post-streptococcal glomerulonephritis. |
| المؤلفون: |
Okada K; Department of Pediatrics, School of Medicine, University of Tokushima, Japan., Katano T, Kamogashira T, Zahn RJ, Morimito Y, Kagami S, Yasutomo K, Kuhara T, Kuroda Y |
| المصدر: |
Clinical nephrology [Clin Nephrol] 1995 Jul; Vol. 44 (1), pp. 8-13. |
| نوع المنشور: |
Comparative Study; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Print ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle. |
| مواضيع طبية MeSH: |
Genes, Bacterial/*genetics , Glomerulonephritis/*microbiology , Streptococcal Infections/*complications , Streptococcus pyogenes/*enzymology , Streptococcus pyogenes/*genetics , Streptokinase/*genetics, Adolescent ; Amino Acid Sequence ; Case-Control Studies ; Child ; Female ; Humans ; Immunoblotting ; Male ; Molecular Sequence Data ; Polymerase Chain Reaction ; Respiratory Tract Infections/microbiology ; Streptokinase/classification |
| مستخلص: |
To investigate a possible causal role of streptokinase (SKase) in acute post-streptococcal glomerulonephritis (APSGN), the major variable region of SKase genes of Streptococcus pyogenes strains isolated from patients with and without APSGN were analyzed using the polymerase chain reaction, restriction enzyme analysis and the direct sequencing of SKase genes. In the APSGN-associated strains, six of nine revealed mutant classes corresponding to the nephritogenic classes I and II proposed by Johnston et al. [1992], the remaining three belonged to non-nephritogenic classes. In twenty strains not associated with APSGN, seventeen belonged to classes I and II, while three were from other classes. The major variable region of the SKase gene shows no apparent relation with induction of APSGN in humans, suggesting that unique classes of streptococcal SKase do not play a role in the pathogenesis of APSGN. |
| المشرفين على المادة: |
EC 3.4.- (Streptokinase) |
| تواريخ الأحداث: |
Date Created: 19950701 Date Completed: 19951109 Latest Revision: 20061115 |
| رمز التحديث: |
20240627 |
| PMID: |
7554538 |
| قاعدة البيانات: |
MEDLINE |
