دورية أكاديمية
Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis.
| العنوان: | Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis. |
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| المؤلفون: | Kuijpers AL; Department of Dermatology, University Hospital Nijmegen, The Netherlands., Alkemade HA, Schalkwijk J, van de Kerkhof PC |
| المصدر: | Acta dermato-venereologica [Acta Derm Venereol] 1995 Mar; Vol. 75 (2), pp. 110-3. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Print Cited Medium: Print ISSN: 0001-5555 (Print) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Uppsala, Sweden : MJS Publishing Original Publication: Stockholm : Acta dermato-venereologica |
| مواضيع طبية MeSH: | Proteins*, Pancreatic Elastase/*metabolism , Psoriasis/*enzymology , Serine Proteinase Inhibitors/*metabolism, Aged ; Biopsy ; Epidermis/metabolism ; Epidermis/pathology ; Female ; Humans ; Immunohistochemistry ; Leukocyte Elastase ; Leukocytes/metabolism ; Proteinase Inhibitory Proteins, Secretory ; Psoriasis/pathology |
| مستخلص: | We have assessed the distribution pattern of a new epidermal elastase inhibitor, skin-derived antileukoproteinase (SKALP) and polymorphonuclear leukocytes (PMN) in a patient with annular pustular psoriasis, using immunohistochemical methods. In clinically uninvolved skin SKALP was not expressed and only occasionally a few PMN could be identified. In the erythematous distal margin of the lesion, expression of SKALP was shown in suprabasal keratinocytes. Although PMN were present in the dermis, no transepidermal PMN migration had occurred at this stage. In the pustular region a dense SKALP-positive zone was demonstrated in the suprabasal compartment. In the centrally healed area neither SKALP expression nor PMN accumulation was shown. The present case report suggests that the induction of SKALP expression does not result from the passage of PMN through the epidermis. The offswitch of SKALP expression coincides with the disappearance of the PMN infiltration and not with the resolution of the mononuclear infiltrate. |
| المشرفين على المادة: | 0 (Proteinase Inhibitory Proteins, Secretory) 0 (Proteins) 0 (Serine Proteinase Inhibitors) EC 3.4.21.36 (Pancreatic Elastase) EC 3.4.21.37 (Leukocyte Elastase) |
| تواريخ الأحداث: | Date Created: 19950301 Date Completed: 19950809 Latest Revision: 20190201 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2340/0001555575110113 |
| PMID: | 7604637 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0001-5555 |
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| DOI: | 10.2340/0001555575110113 |