دورية أكاديمية
In vivo non-invasive quantification of muscle damage following a single intramuscular injection of phenylbutazone in sheep.
| العنوان: | In vivo non-invasive quantification of muscle damage following a single intramuscular injection of phenylbutazone in sheep. |
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| المؤلفون: | Houpert P; Departement de Physiopathologie, Ecole Nationale Veterinaire, Toulouse, France., Serthelon JP, Lefebvre HP, Toutain PL, Braun JP |
| المصدر: | Veterinary and human toxicology [Vet Hum Toxicol] 1995 Apr; Vol. 37 (2), pp. 105-10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American College of Veterinary Toxicologists Country of Publication: United States NLM ID: 7704194 Publication Model: Print Cited Medium: Print ISSN: 0145-6296 (Print) Linking ISSN: 01456296 NLM ISO Abbreviation: Vet Hum Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Manhattan, Kan., American College of Veterinary Toxicologists. |
| مواضيع طبية MeSH: | Creatine Kinase/*metabolism , Injections, Intramuscular/*veterinary , Muscle, Skeletal/*drug effects , Phenylbutazone/*adverse effects, Animals ; Buttocks ; Creatine Kinase/blood ; Female ; Injections, Intramuscular/adverse effects ; Injections, Intravenous/veterinary ; Muscle, Skeletal/enzymology ; Neck Muscles/drug effects ; Phenylbutazone/administration & dosage ; Phenylbutazone/blood ; Sheep |
| مستخلص: | Intramuscular drug administration can lead to more or less extensive muscle damage. The aim of the present study was to show the possibility of quantitating, in vivo and non-invasively, the equivalence of muscle destroyed by the administration of a test drug (phenylbutazone) known for its injurious properties. Creatine kinase (CK) kinetic parameters (clearance, volume of distribution) were measured in 6 sheep after an iv administration of muscle CK homogenate. In the same 6 sheep, CK release after iv and im 8 mg phenylbutazone/kg was measured. The calculated total CK released, based on the CK plasma clearance (0.28 mL/kg/min) and area under the curve of CK activity after im phenylbutazone administration was 191 +/- 140 U/kg. By relating this quantity to that of CK gluteal muscle (5114 +/- 891 U/g), it was calculated that im phenylbutazone administration was able to destroy an equivalence of 2.4 +/- 2.1 g of muscle. For the 2 main sites of im administration (neck and gluteal muscle), general equations are proposed to calculate the equivalence of muscle destroyed in sheep when only plasma CK activity following a test drug administration is available. |
| المشرفين على المادة: | EC 2.7.3.2 (Creatine Kinase) GN5P7K3T8S (Phenylbutazone) |
| تواريخ الأحداث: | Date Created: 19950401 Date Completed: 19950901 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 7631487 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0145-6296 |
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