دورية أكاديمية
High frequency of detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in biopsies from malignant and premalignant skin lesions from renal transplant recipients.
| العنوان: | High frequency of detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in biopsies from malignant and premalignant skin lesions from renal transplant recipients. |
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| المؤلفون: | de Jong-Tieben LM; Department of Dermatology, University Hospital Leiden, The Netherlands., Berkhout RJ, Smits HL, Bouwes Bavinck JN, Vermeer BJ, van der Woude FJ, ter Schegget J |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 1995 Sep; Vol. 105 (3), pp. 367-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print Cited Medium: Print ISSN: 0022-202X (Print) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Kidney Transplantation*, DNA, Viral/*analysis , Epidermodysplasia Verruciformis/*virology , Papillomaviridae/*genetics , Precancerous Conditions/*virology , Skin Neoplasms/*virology, Adult ; Aged ; Biopsy ; Epidermodysplasia Verruciformis/genetics ; Female ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Skin/pathology ; Skin/virology |
| مستخلص: | Based on immunologic and epidemiologic data, it is plausible that skin cancer in renal transplant recipients is associated with human papillomaviruses (HPV). At present, conflicting evidence exists concerning the presence of HPV DNA in these cancers. We recently described a nested polymerase chain reaction method that enables the detection of all previously isolated epidermodysplasia verruciformis (EV)-associated HPVs. We now describe the detection of EV-associated HPV DNA in 49 (80%) of 61 biopsies from squamous cell carcinomas, in four (50%) of eight basal cell carcinomas, in 14 (93%) of 15 actinic keratoses, in two (40%) of five cases of Bowen's disease, and in four (57%) of seven keratoacanthomas. HPV DNA typing revealed that all detected HPV types belonged to the EV-associated HPV types. A wide spectrum of EV-associated HPVs was found, including six putative new HPV types. In a high percentage of the lesions more than one HPV type was detected. We often found the same HPV types in different skin biopsies from both malignant and premalignant lesions from the same patient. The high frequency of detection of EV-associated HPV types in biopsies from malignant and premalignant lesions is in agreement with the hypothesis that EV-associated HPVs are involved in the pathogenesis of skin cancer in renal transplant recipients. |
| المشرفين على المادة: | 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 19950901 Date Completed: 19951012 Latest Revision: 20190723 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1111/1523-1747.ep12320803 |
| PMID: | 7665914 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-202X |
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| DOI: | 10.1111/1523-1747.ep12320803 |