دورية أكاديمية
Beta-adrenergic receptor changes in learned helplessness may depend on stress and test parameters.
| العنوان: | Beta-adrenergic receptor changes in learned helplessness may depend on stress and test parameters. |
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| المؤلفون: | Brannan SK; Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA., Miller A, Jones DJ, Kramer GL, Petty F |
| المصدر: | Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1995 Jun-Jul; Vol. 51 (2-3), pp. 553-6. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print Cited Medium: Print ISSN: 0091-3057 (Print) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Original Publication: Phoenix, N. Y. Ankho International, ltd. |
| مواضيع طبية MeSH: | Helplessness, Learned*, Brain Chemistry/*physiology , Receptors, Adrenergic, beta/*metabolism , Stress, Psychological/*metabolism, Animals ; Cerebellum/metabolism ; Electroshock ; Hippocampus/metabolism ; Iodocyanopindolol ; Kinetics ; Male ; Pindolol/analogs & derivatives ; Prefrontal Cortex/metabolism ; Rats ; Rats, Wistar ; Stress, Psychological/psychology |
| مستخلص: | Behavioral deficits following inescapable stress (learned helplessness) may serve as an animal model of depression. Previous studies using foot-shock stress to induce learned helplessness and a bar-press test for the stress-induced behavioral deficit have found increased beta-adrenergic receptor density in the hippocampus of learned helpless rats. We replicated these experiments using a tail-shock stress and the shuttle-box test. In our experiments, rats that developed learned helplessness after inescapable stress did not demonstrate any significant differences in beta-adrenergic receptor density or affinity in the frontal cortex, cerebellum, or hippocampus compared to the nonhelpless rats, nor to the tested control rats. These results suggest that beta-adrenergic receptor changes in learned helplessness may depend on the specific stress and test procedures used. |
| المشرفين على المادة: | 0 (Receptors, Adrenergic, beta) 83498-72-0 (Iodocyanopindolol) BJ4HF6IU1D (Pindolol) |
| تواريخ الأحداث: | Date Created: 19950601 Date Completed: 19951011 Latest Revision: 20190712 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0091-3057(95)00054-z |
| PMID: | 7667386 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0091-3057 |
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| DOI: | 10.1016/0091-3057(95)00054-z |