دورية أكاديمية
Localization of GM1 and Gal(beta 1-3)GalNAc antigenic determinants in peripheral nerve.
| العنوان: | Localization of GM1 and Gal(beta 1-3)GalNAc antigenic determinants in peripheral nerve. |
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| المؤلفون: | Corbo M; Department of Pathology (Division of Neuropathology), Columbia Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032., Quattrini A, Latov N, Hays AP |
| المصدر: | Neurology [Neurology] 1993 Apr; Vol. 43 (4), pp. 809-14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print Cited Medium: Print ISSN: 0028-3878 (Print) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Minneapolis. |
| مواضيع طبية MeSH: | Antigens, Tumor-Associated, Carbohydrate/*immunology , Epitopes/*analysis , G(M1) Ganglioside/*immunology , Peripheral Nerves/*chemistry, Animals ; Arachis ; Cholera Toxin/pharmacokinetics ; Humans ; Lectins/pharmacokinetics ; Microscopy, Fluorescence ; Peanut Agglutinin ; Plant Lectins ; Rats ; Reference Values ; Sciatic Nerve/chemistry ; Staining and Labeling ; Sural Nerve/chemistry |
| مستخلص: | Anti-GM1 antibodies in patients with motor neuropathy or motor neuron disease frequently recognize the Gal(beta 1-3)GalNAc epitope, which is shared by several glycoproteins in peripheral nerve. In this study, cholera toxin (CT), which is specific for GM1, and the lectin peanut agglutinin (PNA), which binds to Gal(beta 1-3)GalNAc-bearing glycoproteins, were used in tissue section and intraneural injection studies to examine the distribution of GM1 and Gal(beta 1-3)GalNAc epitopes in human and rat peripheral nerve by epifluorescence and confocal microscopy. In tissue sections, CT stained the compact myelin in both human and rat nerves, whereas PNA was localized at the outer edge of the myelin sheath or Schwann cell membrane. Following intraneural injection into rat sciatic nerves, both CT and PNA bound to the nodes of Ranvier, although CT was concentrated in the paranodal myelin region whereas PNA was concentrated at the nodal gap. These structures may be targets for anti-GM1 antibodies in peripheral nerve. |
| معلومات مُعتمدة: | NS11766 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Antigens, Tumor-Associated, Carbohydrate) 0 (Epitopes) 0 (Lectins) 0 (Peanut Agglutinin) 0 (Plant Lectins) 3554-90-3 (Thomsen-Friedenreich antigen) 37758-47-7 (G(M1) Ganglioside) 9012-63-9 (Cholera Toxin) |
| تواريخ الأحداث: | Date Created: 19930401 Date Completed: 19930511 Latest Revision: 20190514 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1212/wnl.43.4.809 |
| PMID: | 7682302 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0028-3878 |
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| DOI: | 10.1212/wnl.43.4.809 |